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Title: Para-Hydrogen-Enhanced Gas-Phase Magnetic Resonance Imaging

Abstract

Herein, we demonstrate magnetic resonance imaging (MRI) inthe gas phase using para-hydrogen (p-H2)-induced polarization. A reactantmixture of H2 enriched in the paraspin state and propylene gas is flowedthrough a reactor cell containing a heterogenized catalyst, Wilkinson'scatalyst immobilized on modified silica gel. The hydrogenation product,propane gas, is transferred to the NMR magnet and is spin-polarized as aresult of the ALTADENA (adiabatic longitudinal transport and dissociationengenders net alignment) effect. A polarization enhancement factor of 300relative to thermally polarized gas was observed in 1D1H NMR spectra.Enhancement was also evident in the magnetic resonance images. This isthe first demonstration of imaging a hyperpolarized gaseous productformed in a hydrogenation reaction catalyzed by a supported catalyst.This result may lead to several important applications, includingflow-through porous materials, gas-phase reaction kinetics and adsorptionstudies, and MRI in low fields, all using catalyst-free polarizedfluids.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org.:
USDOE Director. Office of Science. Office of Basic EnergySciences; US Department of Homeland Securities ContractDE-AC05-06OR23100; Russian Science Support foundation
OSTI Identifier:
923362
Report Number(s):
LBNL-63262
R&D Project: 508601; BnR: KC0203010; TRN: US200804%%1087
DOE Contract Number:  
DE-AC02-05CH11231
Resource Type:
Journal Article
Resource Relation:
Journal Name: Angewandte Chemie International Edition; Journal Volume: 46; Journal Issue: 22; Related Information: Journal Publication Date: 23 Apr 2007
Country of Publication:
United States
Language:
English
Subject:
36; ADSORPTION; ALIGNMENT; CATALYSTS; DISSOCIATION; HYDROGENATION; MAGNETIC RESONANCE; MAGNETS; MIXTURES; NMR SPECTRA; POLARIZATION; POROUS MATERIALS; PROPANE; PROPYLENE; REACTION KINETICS; REACTOR CELLS; SILICA GEL; altadena heterogeneous catalysis magnetic resonance imaging NMRpara-hydrogen induced polarization

Citation Formats

Bouchard, Louis-S., Kovtunov, Kirill V., Burt, Scott R., Anwar,M. Sabieh, Koptyug, Igor V., Sagdeev, Renad Z., and Pines, Alexander. Para-Hydrogen-Enhanced Gas-Phase Magnetic Resonance Imaging. United States: N. p., 2007. Web. doi:10.1002/anie.200700830.
Bouchard, Louis-S., Kovtunov, Kirill V., Burt, Scott R., Anwar,M. Sabieh, Koptyug, Igor V., Sagdeev, Renad Z., & Pines, Alexander. Para-Hydrogen-Enhanced Gas-Phase Magnetic Resonance Imaging. United States. doi:10.1002/anie.200700830.
Bouchard, Louis-S., Kovtunov, Kirill V., Burt, Scott R., Anwar,M. Sabieh, Koptyug, Igor V., Sagdeev, Renad Z., and Pines, Alexander. Fri . "Para-Hydrogen-Enhanced Gas-Phase Magnetic Resonance Imaging". United States. doi:10.1002/anie.200700830.
@article{osti_923362,
title = {Para-Hydrogen-Enhanced Gas-Phase Magnetic Resonance Imaging},
author = {Bouchard, Louis-S. and Kovtunov, Kirill V. and Burt, Scott R. and Anwar,M. Sabieh and Koptyug, Igor V. and Sagdeev, Renad Z. and Pines, Alexander},
abstractNote = {Herein, we demonstrate magnetic resonance imaging (MRI) inthe gas phase using para-hydrogen (p-H2)-induced polarization. A reactantmixture of H2 enriched in the paraspin state and propylene gas is flowedthrough a reactor cell containing a heterogenized catalyst, Wilkinson'scatalyst immobilized on modified silica gel. The hydrogenation product,propane gas, is transferred to the NMR magnet and is spin-polarized as aresult of the ALTADENA (adiabatic longitudinal transport and dissociationengenders net alignment) effect. A polarization enhancement factor of 300relative to thermally polarized gas was observed in 1D1H NMR spectra.Enhancement was also evident in the magnetic resonance images. This isthe first demonstration of imaging a hyperpolarized gaseous productformed in a hydrogenation reaction catalyzed by a supported catalyst.This result may lead to several important applications, includingflow-through porous materials, gas-phase reaction kinetics and adsorptionstudies, and MRI in low fields, all using catalyst-free polarizedfluids.},
doi = {10.1002/anie.200700830},
journal = {Angewandte Chemie International Edition},
number = 22,
volume = 46,
place = {United States},
year = {Fri Feb 23 00:00:00 EST 2007},
month = {Fri Feb 23 00:00:00 EST 2007}
}