Synthetic Nano-Low Density Lipoprotein as Targeted Drug DeliveryVehicle for Glioblastoma Multiforme

Journal Article · Wed Jun 14 00:00:00 EDT 2006 · International Journal of Pharmaceutics

OSTI ID:923003

Nikanjam, Mina; Blakely, Eleanor A; Bjornstad, Kathleen A; Shu, Xiao; Budinger, Thomas F; Forte, Trudy M

This paper discribes a synthetic low density lipoprotein(LDL) made by complexing a 29 amino acid that consists of a lipid bindingdomain and the LDL receptor binding domain with a lipid microemulsion.The nano-LDL particles were intermdiate in size between LDL and HDL andbound to LDL receptors on GBM brain tumor cells. Synthetic nano-LDLuptake by GBM cells was LDL receptor specific and dependent on cellreceptor number. It is suggested that these synthetic particles can serveas a delivery vehicle for hydophobic anti-tumor drugs by targeting theLDL receptor.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: USDOE Director. Office of Science. Biological andEnvironmental Research
• DOE Contract Number: DE-AC02-05CH11231
• OSTI ID: 923003
• Report Number(s): LBNL-60496; IJPHDE; R&D Project: 440Z01; BnR: KP1102020; TRN: US200804%%834
• Journal Information: International Journal of Pharmaceutics, Vol. 328, Issue 1; Related Information: Journal Publication Date: 07/31/2006; ISSN 0378-5173
• Country of Publication: United States
• Language: English

Related Subjects

60
AMINO ACIDS
BRAIN
GLIOMAS
LIPIDS
LIPOPROTEINS
TUMOR CELLS
LDL receptor microemulsion synthetic nano-LDL