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Title: APTASENSORS FOR BIOSECURITY APPLICATIONS

Abstract

Nucleic acid aptamers have found steadily increased utility and application steadily over the last decade. In particular, aptamers have been touted as a valuable complement to and in some cases replacement for antibodies due to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications, e.g. pathogen detection, and are especially well suited since their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against biopathogens over the last few years. In addition, a few recently described detection platforms using aptamers (aptasensors) and potentially suitable for biosecurity applications will be discussed.

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
919610
Report Number(s):
UCRL-JRNL-227094
TRN: US200822%%445
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Journal Article
Resource Relation:
Journal Name: Current Opinion in Chemical Biology, vol. 11, no. 1, January 7, 2007, pp. 316-328; Journal Volume: 11; Journal Issue: 1
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; ANTIBODIES; DETECTION; FUNCTIONALS; IN VITRO; NUCLEIC ACIDS; PATHOGENS; SYNTHESIS

Citation Formats

Fischer, N, Tarasow, T, and Tok, J. APTASENSORS FOR BIOSECURITY APPLICATIONS. United States: N. p., 2007. Web. doi:10.1016/j.cbpa.2007.05.017.
Fischer, N, Tarasow, T, & Tok, J. APTASENSORS FOR BIOSECURITY APPLICATIONS. United States. doi:10.1016/j.cbpa.2007.05.017.
Fischer, N, Tarasow, T, and Tok, J. Wed . "APTASENSORS FOR BIOSECURITY APPLICATIONS". United States. doi:10.1016/j.cbpa.2007.05.017. https://www.osti.gov/servlets/purl/919610.
@article{osti_919610,
title = {APTASENSORS FOR BIOSECURITY APPLICATIONS},
author = {Fischer, N and Tarasow, T and Tok, J},
abstractNote = {Nucleic acid aptamers have found steadily increased utility and application steadily over the last decade. In particular, aptamers have been touted as a valuable complement to and in some cases replacement for antibodies due to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications, e.g. pathogen detection, and are especially well suited since their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against biopathogens over the last few years. In addition, a few recently described detection platforms using aptamers (aptasensors) and potentially suitable for biosecurity applications will be discussed.},
doi = {10.1016/j.cbpa.2007.05.017},
journal = {Current Opinion in Chemical Biology, vol. 11, no. 1, January 7, 2007, pp. 316-328},
number = 1,
volume = 11,
place = {United States},
year = {Wed Jan 03 00:00:00 EST 2007},
month = {Wed Jan 03 00:00:00 EST 2007}
}