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Title: Convergent evolution in primates and an insectivore

Abstract

The cardiovascular risk factor apolipoprotein(a) (apo(a)) has a puzzling distribution among mammals, its presence being limited to a subset of primates and a member of the insectivore lineage, the hedgehog. To explore the evolutionary history of apo(a), we performed extensive genomic sequence comparisons of multiple species with and without an apo(a) gene product, such as human, baboon, hedgehog, lemurand mouse. This analysis indicated that apo(a) arose independently in a subset of primates, including baboon and human, and an insectivore, the hedgehog, and was not simply lost by species lacking it. The similar structural domains shared by the hedgehog and primate apo(a) indicate that they were formed by a unique molecular mechanism involving the convergent evolution of paralogous genes in these distantspecies.

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Director, Office of Science; National Institutes of Health (NIH)
OSTI Identifier:
917811
Report Number(s):
LBNL-52679
Journal ID: ISSN 0888-7543; GNMCEP; R&D Project: 863V2A; BnR: 400412000; TRN: US200817%%884
DOE Contract Number:
DE-AC02-05CH11231; NIHHL66728
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; Journal Volume: 83; Journal Issue: 1; Conference: 01/2004; Related Information: Journal Publication Date: 01/2004
Country of Publication:
United States
Language:
English
Subject:
60; BABOONS; DISTRIBUTION; GENES; MAMMALS; PRIMATES; CARDIOVASCULAR SYSTEM

Citation Formats

Boffelli, Dario, Cheng, Jan-Fang, and Rubin, Edward M. Convergent evolution in primates and an insectivore. United States: N. p., 2003. Web.
Boffelli, Dario, Cheng, Jan-Fang, & Rubin, Edward M. Convergent evolution in primates and an insectivore. United States.
Boffelli, Dario, Cheng, Jan-Fang, and Rubin, Edward M. Wed . "Convergent evolution in primates and an insectivore". United States. doi:. https://www.osti.gov/servlets/purl/917811.
@article{osti_917811,
title = {Convergent evolution in primates and an insectivore},
author = {Boffelli, Dario and Cheng, Jan-Fang and Rubin, Edward M.},
abstractNote = {The cardiovascular risk factor apolipoprotein(a) (apo(a)) has a puzzling distribution among mammals, its presence being limited to a subset of primates and a member of the insectivore lineage, the hedgehog. To explore the evolutionary history of apo(a), we performed extensive genomic sequence comparisons of multiple species with and without an apo(a) gene product, such as human, baboon, hedgehog, lemurand mouse. This analysis indicated that apo(a) arose independently in a subset of primates, including baboon and human, and an insectivore, the hedgehog, and was not simply lost by species lacking it. The similar structural domains shared by the hedgehog and primate apo(a) indicate that they were formed by a unique molecular mechanism involving the convergent evolution of paralogous genes in these distantspecies.},
doi = {},
journal = {Genomics},
number = 1,
volume = 83,
place = {United States},
year = {Wed Apr 16 00:00:00 EDT 2003},
month = {Wed Apr 16 00:00:00 EDT 2003}
}