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Title: Magnetic separation of micro-spheres from viscous biological fluids.

Abstract

A magnetically based detoxification system is being developed as a therapeutic tool for selective and rapid removal of biohazards, i.e. chemicals and radioactive substances, from human blood. One of the key components of this system is a portable magnetic separator capable of separating polymer-based magnetic nano/micro-spheres from arterial blood flow in an ex vivo unit. The magnetic separator consists of an array of alternating and parallel capillary tubing and magnetizable wires, which is exposed to an applied magnetic field created by two parallel permanent magnets such that the magnetic field is perpendicular to both the wires and the fluid flow. In this paper, the performance of this separator was evaluated via preliminary in vitro flow experiments using a separator unit consisting of single capillary glass tubing and two metal wires. Pure water, ethylene glycol-water solution (v:v = 39:61 and v:v = 49:51) and human whole blood were used as the fluids. The results showed that when the viscosity increased from 1.0 cp to 3.0 cp, the capture efficiency (CE) decreased from 90% to 56%. However, it is still feasible to obtain >90% CE in blood flow if the separator design is optimized to create higher magnetic gradients and magnetic fieldsmore » in the separation area.« less

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
Defense Advanced Research Projects Agency (DARPA); Univ. of Chicago Brain Research; Cancer Research Foundations
OSTI Identifier:
914899
Report Number(s):
ANL/CMT/JA-58164
Journal ID: ISSN 0031-9155; PHMBA7; TRN: US200817%%3
DOE Contract Number:  
DE-AC02-06CH11357
Resource Type:
Journal Article
Resource Relation:
Journal Name: Phys. Med. Biol.; Journal Volume: 52; Journal Issue: 4 ; Feb. 21, 2007
Country of Publication:
United States
Language:
ENGLISH
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; SEPARATION PROCESSES; MICROSPHERES; BLOOD; BLOOD FLOW; IN VITRO; MAGNETIC SEPARATORS; RADIOISOTOPES; TOXIC MATERIALS; PERFORMANCE; VISCOSITY

Citation Formats

Chen, H., Kaminski, M. D., Xianqiao, L., Caviness, P., Torno, M., Rosengart, A. J., Dhar, P., Chemical Engineering, Univ. of Chicago Pritzker School of Medicine, and Illinois Inst. of Tech. Magnetic separation of micro-spheres from viscous biological fluids.. United States: N. p., 2007. Web. doi:10.1088/0031-9155/52/4/022.
Chen, H., Kaminski, M. D., Xianqiao, L., Caviness, P., Torno, M., Rosengart, A. J., Dhar, P., Chemical Engineering, Univ. of Chicago Pritzker School of Medicine, & Illinois Inst. of Tech. Magnetic separation of micro-spheres from viscous biological fluids.. United States. doi:10.1088/0031-9155/52/4/022.
Chen, H., Kaminski, M. D., Xianqiao, L., Caviness, P., Torno, M., Rosengart, A. J., Dhar, P., Chemical Engineering, Univ. of Chicago Pritzker School of Medicine, and Illinois Inst. of Tech. Wed . "Magnetic separation of micro-spheres from viscous biological fluids.". United States. doi:10.1088/0031-9155/52/4/022.
@article{osti_914899,
title = {Magnetic separation of micro-spheres from viscous biological fluids.},
author = {Chen, H. and Kaminski, M. D. and Xianqiao, L. and Caviness, P. and Torno, M. and Rosengart, A. J. and Dhar, P. and Chemical Engineering and Univ. of Chicago Pritzker School of Medicine and Illinois Inst. of Tech.},
abstractNote = {A magnetically based detoxification system is being developed as a therapeutic tool for selective and rapid removal of biohazards, i.e. chemicals and radioactive substances, from human blood. One of the key components of this system is a portable magnetic separator capable of separating polymer-based magnetic nano/micro-spheres from arterial blood flow in an ex vivo unit. The magnetic separator consists of an array of alternating and parallel capillary tubing and magnetizable wires, which is exposed to an applied magnetic field created by two parallel permanent magnets such that the magnetic field is perpendicular to both the wires and the fluid flow. In this paper, the performance of this separator was evaluated via preliminary in vitro flow experiments using a separator unit consisting of single capillary glass tubing and two metal wires. Pure water, ethylene glycol-water solution (v:v = 39:61 and v:v = 49:51) and human whole blood were used as the fluids. The results showed that when the viscosity increased from 1.0 cp to 3.0 cp, the capture efficiency (CE) decreased from 90% to 56%. However, it is still feasible to obtain >90% CE in blood flow if the separator design is optimized to create higher magnetic gradients and magnetic fields in the separation area.},
doi = {10.1088/0031-9155/52/4/022},
journal = {Phys. Med. Biol.},
number = 4 ; Feb. 21, 2007,
volume = 52,
place = {United States},
year = {Wed Feb 21 00:00:00 EST 2007},
month = {Wed Feb 21 00:00:00 EST 2007}
}