Apolipoprotein gene involved in lipid metabolism

Rubin, Edward; Pennacchio, Len A

Apolipoprotein gene involved in lipid metabolism

Patent · 03 July 2007

OSTI ID:913257

Rubin, Edward ^[1]; Pennacchio, Len A ^[2]

Berkeley, CA
Sebastopol, CA

Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA

Sponsoring Organization:: Office of Biological and Environmental Research

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of The University of California (Oakland, CA)

Patent Number(s):: 7,238,475

Application Number:: 10/229,834

OSTI ID:: 913257

Country of Publication:: United States

Language:: English

References (25)

Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of Apolipoprotein A-I in Mice Tangirala, Rajendra K.; Tsukamoto, Kazuhisa; Chun, Sam H. Circulation, Vol. 100, Issue 17 https://doi.org/10.1161/01.CIR.100.17.1816	journal	October 1999
Genetic variation in the apolipoprotein AI-CIII-AIV gene cluster and coronary heart disease Paulweber, Bernhard; Friedl, Walter; Krempler, Franz Atherosclerosis, Vol. 73, Issue 2-3 https://doi.org/10.1016/0021-9150(88)90033-0	journal	October 1988
DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease Aalto-Setälä, Katriina; Kontula, Kimmo; Sane, Timo Atherosclerosis, Vol. 66, Issue 1-2 https://doi.org/10.1016/0021-9150(87)90190-0	journal	July 1987
Haplotypes of the ApoA-I/C-III/A-IV Gene Cluster and Familial Combined Hyperlipidemia Tahvanainen, Esa; Pajukanta, Päivi; Porkka, Kimmo Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 18, Issue 11 https://doi.org/10.1161/01.ATV.18.11.1810	journal	November 1998
Study of DNA polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster in patients with peripheral arterial disease Monsalve, M. V.; Young, R.; Wiseman, S. A. Clinical Science, Vol. 76, Issue 2 https://doi.org/10.1042/cs0760221	journal	February 1989
Increased risk for endogenous hypertriglyceridaemia is associated with an apolipoprotein C3 haplotype specified by theSstI polymorphism Hoffer, M. J.; Sijbrands, E. J.; De Man, F. H. European Journal of Clinical Investigation, Vol. 28, Issue 10, p. 807-812 https://doi.org/10.1046/j.1365-2362.1998.00361.x	journal	October 1998
A Genome Scan for Familial Combined Hyperlipidemia Reveals Evidence of Linkage with a Locus on Chromosome 11 Aouizerat, Bradley E.; Allayee, Hooman; Cantor, Rita M. The American Journal of Human Genetics, Vol. 65, Issue 2 https://doi.org/10.1086/302490	journal	August 1999
An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms. Dammerman, M.; Sandkuijl, L. A.; Halaas, J. L. Proceedings of the National Academy of Sciences, Vol. 90, Issue 10 https://doi.org/10.1073/pnas.90.10.4562	journal	May 1993
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides Talmud, P. J. Human Molecular Genetics, Vol. 11, Issue 24 https://doi.org/10.1093/hmg/11.24.3039	journal	November 2002
Genetic markers in the apo AI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis Tybjærg-Hansen, Anne; Nordestgaard, Børge G.; Gerdes, Lars Ulrik Atherosclerosis, Vol. 100, Issue 2 https://doi.org/10.1016/0021-9150(93)90202-6	journal	May 1993
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing Pennacchio, L. A. Science, Vol. 294, Issue 5540 https://doi.org/10.1126/science.1064852	journal	October 2001
ApoC-III gene polymorphisms and risk of coronary artery disease Olivieri, Oliviero; Stranieri, Chiara; Bassi, Antonella Journal of Lipid Research, Vol. 43, Issue 9 https://doi.org/10.1194/jlr.M200145-JLR200	journal	September 2002
Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia Surguchov, Andrei P.; Page, Grier P.; Smith, Louis Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 16, Issue 8 https://doi.org/10.1161/01.ATV.16.8.941	journal	August 1996
DNA Polymorphisms of the Apolipoprotein AI/CIII/ AIV Gene Cluster Influence Plasma Cholesterol and Triglyceride Levels in the Mayans of the Yucatán Peninsula, Mexico Ahn, Y. I.; Valdez, R.; Reddy, A. P. Human Heredity, Vol. 41, Issue 5 https://doi.org/10.1159/000154014	journal	January 1991
Dna Polymorphism Adjacent to Human Apoprotein a-1 Gene: Relation to Hypertriglyceridaemia Rees, A.; Stocks, J.; Shoulders, C. C. The Lancet, Vol. 321, Issue 8322 https://doi.org/10.1016/S0140-6736(83)91440-X	journal	February 1983
Two newly identified SNPs in the APO AI-CIII intergenic region are strongly associated with familial combined hyperlipidaemia Groenendijk, M.; Cantor, R. M.; Funke, H. European Journal of Clinical Investigation, Vol. 31, Issue 10 https://doi.org/10.1046/j.1365-2362.2001.00888.x	journal	October 2001
HTS in the new millennium Landro, James A.; Taylor, Ian C. A.; Stirtan, William G. Journal of Pharmacological and Toxicological Methods, Vol. 44, Issue 1 https://doi.org/10.1016/S1056-8719(00)00108-8	journal	July 2000
The apoAI-CIII-AIV gene cluster Groenendijk, M. Atherosclerosis, Vol. 157, Issue 1 https://doi.org/10.1016/S0021-9150(01)00539-1	journal	July 2001
The essence of SNPs Brookes, Anthony J. Gene, Vol. 234, Issue 2 https://doi.org/10.1016/S0378-1119(99)00219-X	journal	July 1999
The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese Nabika, Toru; Nasreen, Shampa; Kobayashi, Shotai Atherosclerosis, Vol. 165, Issue 2 https://doi.org/10.1016/S0021-9150(02)00252-6	journal	December 2002
Variation at the apo AI/CIII/A1V gene complex is associated with elevated plasma levels of apo CIII Shoulders, C. C.; Harry, P. J.; Lagrost, L. Atherosclerosis, Vol. 87, Issue 2-3 https://doi.org/10.1016/0021-9150(91)90026-Y	journal	April 1991
Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels Pennacchio, L. A. Human Molecular Genetics, Vol. 11, Issue 24 https://doi.org/10.1093/hmg/11.24.3031	journal	November 2002
Two polymorphisms in the apo A-IV gene and familial combined hyperlipidemia Groenendijk, M. Atherosclerosis, Vol. 158, Issue 2 https://doi.org/10.1016/S0021-9150(01)00460-9	journal	October 2001
Apolipoprotein A-V: A NOVEL APOLIPOPROTEIN ASSOCIATED WITH AN EARLY PHASE OF LIVER REGENERATION van der Vliet, Hendrik N.; Sammels, Martijn Groenink; Leegwater, Aad C. J. Journal of Biological Chemistry, Vol. 276, Issue 48 https://doi.org/10.1074/jbc.M106888200	journal	September 2001
Variation in the apo AI/CIII/AIV gene complex: its association with hyperlipidemia Shoulders, Carol C.; Ball, Madeline J.; Baralle, Francisco E. Atherosclerosis, Vol. 80, Issue 2 https://doi.org/10.1016/0021-9150(89)90018-X	journal	December 1989

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