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Title: Apolipoprotein gene involved in lipid metabolism

Abstract

Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

Inventors:
 [1];  [2]
  1. Berkeley, CA
  2. Sebastopol, CA
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
Office of Biological and Environmental Research
OSTI Identifier:
913257
Patent Number(s):
7,238,475
Application Number:
10/229,834
Assignee:
The Regents of The University of California (Oakland, CA) OAK
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rubin, Edward, and Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States: N. p., 2007. Web.
Rubin, Edward, & Pennacchio, Len A. Apolipoprotein gene involved in lipid metabolism. United States.
Rubin, Edward, and Pennacchio, Len A. Tue . "Apolipoprotein gene involved in lipid metabolism". United States. https://www.osti.gov/servlets/purl/913257.
@article{osti_913257,
title = {Apolipoprotein gene involved in lipid metabolism},
author = {Rubin, Edward and Pennacchio, Len A},
abstractNote = {Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {7}
}

Patent:

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