Foldable polymers as probes

Patent · 03 July 2007

OSTI ID:913254

Li, Alexander D. Q. ^[1]; Wang, Wei ^[1]

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1. Pullman, WA

Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• Sponsoring Organization: United States Department of Energy
• DOE Contract Number: W-7405-ENG-36
• Assignee: Washington State University Research Foundation (Pullman, WA)
• Patent Number(s): 7,238,792
• Application Number: 10/803,564
• OSTI ID: 913254
• Country of Publication: United States
• Language: English

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