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Title: Sample preparation system for microfluidic applications

Abstract

An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.

Inventors:
 [1];  [2];  [3];  [4]
  1. San Francisco, CA
  2. Fremont, CA
  3. Dublin, CA
  4. Livermore, CA
Publication Date:
Research Org.:
Sandia National Laboratories (SNL-CA), Livermore, CA
Sponsoring Org.:
USDOE
OSTI Identifier:
909334
Patent Number(s):
7,213,473
Application Number:
11/016,310
Assignee:
Sandia National Laboratories (Livermore, CA) ALO
DOE Contract Number:
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, and Harnett, Cindy K. Sample preparation system for microfluidic applications. United States: N. p., 2007. Web.
Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, & Harnett, Cindy K. Sample preparation system for microfluidic applications. United States.
Mosier, Bruce P, Crocker, Robert W, Patel, Kamlesh D, and Harnett, Cindy K. Tue . "Sample preparation system for microfluidic applications". United States. doi:. https://www.osti.gov/servlets/purl/909334.
@article{osti_909334,
title = {Sample preparation system for microfluidic applications},
author = {Mosier, Bruce P and Crocker, Robert W and Patel, Kamlesh D and Harnett, Cindy K},
abstractNote = {An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 08 00:00:00 EDT 2007},
month = {Tue May 08 00:00:00 EDT 2007}
}

Patent:

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