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Title: High pressure capillary micro-fluidic valve device and a method of fabricating same

Patent ·
OSTI ID:908976

A freeze-thaw valve and a method of micro-machining the freeze-thaw valve is provided and includes a valve housing, wherein the valve housing defines a housing cavity and includes a housing inlet, a housing vent, a capillary tubing inlet and a capillary tubing outlet. A valve body is provided, at least a portion of which is lithographically constructed, wherein the valve body includes a refrigerant inlet, a refrigerant outlet and an expansion chamber. The expansion chamber is disposed to communicate the refrigerant inlet with the refrigerant outlet and includes a restriction region having a flow restriction. Additionally, the valve body is disposed within the housing cavity to form an insulating channel between the valve housing and the valve body.

Research Organization:
Waters Investments Ltd. (New Castle, DE)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Waters Investments Ltd. (New Castle, DE)
Patent Number(s):
7,204,264
OSTI ID:
908976
Country of Publication:
United States
Language:
English

References (5)

Ultrahigh-Pressure Reversed-Phase Liquid Chromatography in Packed Capillary Columns journal March 1997
Ultrahigh-Pressure Reversed-Phase Capillary Liquid Chromatography:  Isocratic and Gradient Elution Using Columns Packed with 1.0-μm Particles journal February 1999
Freeze-thaw flow management: a novel concept for high-performance liquid chromatography, capillary electrophoresis, electrochromatography and associated techniques journal April 1995
The Stableflow Pump−a low‐noise and drift‐free pump for high performance liquid chromatography journal June 1991
Automated and Integrated System for High-Throughput DNA Genotyping Directly from Blood journal March 1999

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