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Title: High-Resolution Adaptive Optics Scanning Laser Ophthalmoscope with Dual Deformable Mirrors

Abstract

Adaptive optics scanning laser ophthalmoscope (AO SLO) has demonstrated superior optical quality of non-invasive view of the living retina, but with limited capability of aberration compensation. In this paper, we demonstrate that the use of dual deformable mirrors can effectively compensate large aberrations in the human retina. We used a bimorph mirror to correct large-stroke, low-order aberrations and a MEMS mirror to correct low-stroke, high-order aberration. The measured ocular RMS wavefront error of a test subject was 240 nm without AO compensation. We were able to reduce the RMS wavefront error to 90 nm in clinical settings using one deformable mirror for the phase compensation and further reduced the wavefront error to 48 nm using two deformable mirrors. Compared with that of a single-deformable-mirror SLO system, dual AO SLO offers much improved dynamic range and better correction of the wavefront aberrations. The use of large-stroke deformable mirrors provided the system with the capability of axial sectioning different layers of the retina. We have achieved diffraction-limited in-vivo retinal images of targeted retinal layers such as photoreceptor layer, blood vessel layer and nerve fiber layers with the combined phase compensation of the two deformable mirrors in the AO SLO.

Authors:
; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
907863
Report Number(s):
UCRL-JRNL-225225
TRN: US200721%%433
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Journal Article
Journal Name:
Journal of Optical Society of America, A, vol. 24, no. 5, April 11, 2007, pp. 1305
Additional Journal Information:
Journal Volume: 24; Journal Issue: 5
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUMM MECHANICS, GENERAL PHYSICS; 59 BASIC BIOLOGICAL SCIENCES; BLOOD VESSELS; FIBERS; IN VIVO; LASERS; MIRRORS; NERVES; OPTICS; RETINA

Citation Formats

Chen, D C, Jones, S M, Silva, D A, and Olivier, S S. High-Resolution Adaptive Optics Scanning Laser Ophthalmoscope with Dual Deformable Mirrors. United States: N. p., 2006. Web.
Chen, D C, Jones, S M, Silva, D A, & Olivier, S S. High-Resolution Adaptive Optics Scanning Laser Ophthalmoscope with Dual Deformable Mirrors. United States.
Chen, D C, Jones, S M, Silva, D A, and Olivier, S S. Fri . "High-Resolution Adaptive Optics Scanning Laser Ophthalmoscope with Dual Deformable Mirrors". United States. https://www.osti.gov/servlets/purl/907863.
@article{osti_907863,
title = {High-Resolution Adaptive Optics Scanning Laser Ophthalmoscope with Dual Deformable Mirrors},
author = {Chen, D C and Jones, S M and Silva, D A and Olivier, S S},
abstractNote = {Adaptive optics scanning laser ophthalmoscope (AO SLO) has demonstrated superior optical quality of non-invasive view of the living retina, but with limited capability of aberration compensation. In this paper, we demonstrate that the use of dual deformable mirrors can effectively compensate large aberrations in the human retina. We used a bimorph mirror to correct large-stroke, low-order aberrations and a MEMS mirror to correct low-stroke, high-order aberration. The measured ocular RMS wavefront error of a test subject was 240 nm without AO compensation. We were able to reduce the RMS wavefront error to 90 nm in clinical settings using one deformable mirror for the phase compensation and further reduced the wavefront error to 48 nm using two deformable mirrors. Compared with that of a single-deformable-mirror SLO system, dual AO SLO offers much improved dynamic range and better correction of the wavefront aberrations. The use of large-stroke deformable mirrors provided the system with the capability of axial sectioning different layers of the retina. We have achieved diffraction-limited in-vivo retinal images of targeted retinal layers such as photoreceptor layer, blood vessel layer and nerve fiber layers with the combined phase compensation of the two deformable mirrors in the AO SLO.},
doi = {},
journal = {Journal of Optical Society of America, A, vol. 24, no. 5, April 11, 2007, pp. 1305},
number = 5,
volume = 24,
place = {United States},
year = {2006},
month = {8}
}