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Title: Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)

Abstract

Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as .about.3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.

Inventors:
 [1];  [1];  [1]
  1. Richland, WA
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA
Sponsoring Org.:
USDOE
OSTI Identifier:
902910
Patent Number(s):
7,170,053
Application Number:
11/097,855
Assignee:
Battelle Memorial Institute (Richland, WA) BMI
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Shvartsburg, Alexandre A, Tang, Keqi, and Smith, Richard D. Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD). United States: N. p., 2007. Web.
Shvartsburg, Alexandre A, Tang, Keqi, & Smith, Richard D. Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD). United States.
Shvartsburg, Alexandre A, Tang, Keqi, and Smith, Richard D. Tue . "Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)". United States. doi:. https://www.osti.gov/servlets/purl/902910.
@article{osti_902910,
title = {Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)},
author = {Shvartsburg, Alexandre A and Tang, Keqi and Smith, Richard D},
abstractNote = {Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as .about.3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 30 00:00:00 EST 2007},
month = {Tue Jan 30 00:00:00 EST 2007}
}

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