skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)

Abstract

Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as .about.3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.

Inventors:
 [1];  [1];  [1]
  1. Richland, WA
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
902910
Patent Number(s):
7,170,053
Application Number:
11/097,855
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Shvartsburg, Alexandre A, Tang, Keqi, and Smith, Richard D. Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD). United States: N. p., 2007. Web.
Shvartsburg, Alexandre A, Tang, Keqi, & Smith, Richard D. Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD). United States.
Shvartsburg, Alexandre A, Tang, Keqi, and Smith, Richard D. 2007. "Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)". United States. https://www.osti.gov/servlets/purl/902910.
@article{osti_902910,
title = {Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)},
author = {Shvartsburg, Alexandre A and Tang, Keqi and Smith, Richard D},
abstractNote = {Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that "locks" the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as .about.3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.},
doi = {},
url = {https://www.osti.gov/biblio/902910}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {1}
}

Works referenced in this record:

Backbone Dipoles Generate Positive Potentials in all Proteins: Origins and Implications of the Effect
journal, March 2000


Absolute Values of the Electron Mobility in Hydrogen
journal, March 1936


Evaluation of suspected interferents for TNT detection by ion mobility spectrometry
journal, March 2001


Separation of protein conformers using electrospray-high field asymmetric waveform ion mobility spectrometry-mass spectrometry
journal, February 2000


A pulsed corona discharge switchable high resolution ion mobility spectrometer-mass spectrometer
journal, December 2002


Understanding and Designing Field Asymmetric Waveform Ion Mobility Spectrometry Separations in Gas Mixtures
journal, December 2004


Development and evaluation of a nano-electrospray ionisation source for atmospheric pressure ion mobility spectrometry
journal, October 2002


Modeling the resolution and sensitivity of FAIMS analyses
journal, October 2004


High-resolution ion mobility measurements
journal, February 1997


Laser probing of the rotational alignment of N + 2 drifted in helium
journal, November 1987