A conserved checkpoint monitors meiotic chromosome synapsis inCaenorhabditis elegans
Journal Article
·
· Science
OSTI ID:901805
We report the discovery of a checkpoint that monitorssynapsis between homologous chromosomes to ensure accurate meioticsegregation. Oocytes containing unsynapsed chromosomes selectivelyundergo apoptosis even if agermline DNA damage checkpoint is inactivated.This culling mechanism isspecifically activated by unsynapsed pairingcenters, cis-acting chromosomesites that are also required to promotesynapsis in Caenorhabditis elegans. Apoptosis due to synaptic failurealso requires the C. elegans homolog of PCH2,a budding yeast pachytenecheckpoint gene, which suggests that this surveillance mechanism iswidely conserved.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE; National Institutes of Health Grants 1 F32GM67408-01A1 and 1 R01 GM/CA655591-01; Burroughs Wellcome Career Award1000950
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 901805
- Report Number(s):
- LBNL-58820; SCEHDK; R&D Project: 862E2B; BnR: 400412000; TRN: US200715%%143
- Journal Information:
- Science, Vol. 310, Issue 5754; Related Information: Journal Publication Date: 9 December2005; ISSN 0193-4511
- Country of Publication:
- United States
- Language:
- English
Similar Records
ZHP-3 Acts at Crossovers to Couple Meiotic Recombination with Synaptonemal Complex Disassembly and Bivalent Formation in C. elegans
Identification of DSB-1, a Protein Required for Initiation of Meiotic Recombination in Caenorhabditis elegans, Illuminates a Crossover Assurance Checkpoint
Checkpoint kinases are required for oocyte meiotic progression by the maintenance of normal spindle structure and chromosome condensation
Journal Article
·
Fri Oct 24 00:00:00 EDT 2008
· PLoS Genetics
·
OSTI ID:901805
+1 more
Identification of DSB-1, a Protein Required for Initiation of Meiotic Recombination in Caenorhabditis elegans, Illuminates a Crossover Assurance Checkpoint
Journal Article
·
Thu Aug 08 00:00:00 EDT 2013
· PLoS Genetics
·
OSTI ID:901805
+3 more
Checkpoint kinases are required for oocyte meiotic progression by the maintenance of normal spindle structure and chromosome condensation
Journal Article
·
Sun Aug 15 00:00:00 EDT 2021
· Experimental Cell Research
·
OSTI ID:901805
+2 more