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Title: Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants

Abstract

Atomic force microscopy was used to “fish” for binding reactions between a fibronectin-coated probe (i.e., substrate simulating an implant device) and each of 15 different strains of S. aureus isolated from either patients with infected cardiac prosthesis (invasive group) or healthy human subjects (control group). There is a strong distinction (p=0.01) in the binding force-signature observed for the invasive vs. control populations. This observation suggests that a microorganism’s “force taxonomy” may provide a fundamental and practical indicator of the risk that bacterial infections pose to patients with implanted medical devices.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
901181
Report Number(s):
PNNL-SA-52975
Journal ID: ISSN 0743-7463; LANGD5; 19602; 9593; KP1704020; TRN: US200713%%84
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Langmuir, 23:2289-2292; Journal Volume: 23
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; PATIENTS; STAPHYLOCOCCUS; TAXONOMY; MECHANICAL HEART; BIOLOGICAL INDICATORS; AFM, binding, Staphylococcus aureus; Environmental Molecular Sciences Laboratory

Citation Formats

Yongsunthon, Ruchirej, Fowler, Vance, Lower, Brian H., Vellano, Francis P., Alexander, Emily, Reller, L. Barth, Corey, G. Ralph, and Lower, Steven. Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants. United States: N. p., 2007. Web. doi:10.1021/la063117v.
Yongsunthon, Ruchirej, Fowler, Vance, Lower, Brian H., Vellano, Francis P., Alexander, Emily, Reller, L. Barth, Corey, G. Ralph, & Lower, Steven. Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants. United States. doi:10.1021/la063117v.
Yongsunthon, Ruchirej, Fowler, Vance, Lower, Brian H., Vellano, Francis P., Alexander, Emily, Reller, L. Barth, Corey, G. Ralph, and Lower, Steven. Thu . "Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants". United States. doi:10.1021/la063117v.
@article{osti_901181,
title = {Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants},
author = {Yongsunthon, Ruchirej and Fowler, Vance and Lower, Brian H. and Vellano, Francis P. and Alexander, Emily and Reller, L. Barth and Corey, G. Ralph and Lower, Steven},
abstractNote = {Atomic force microscopy was used to “fish” for binding reactions between a fibronectin-coated probe (i.e., substrate simulating an implant device) and each of 15 different strains of S. aureus isolated from either patients with infected cardiac prosthesis (invasive group) or healthy human subjects (control group). There is a strong distinction (p=0.01) in the binding force-signature observed for the invasive vs. control populations. This observation suggests that a microorganism’s “force taxonomy” may provide a fundamental and practical indicator of the risk that bacterial infections pose to patients with implanted medical devices.},
doi = {10.1021/la063117v},
journal = {Langmuir, 23:2289-2292},
number = ,
volume = 23,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 2007},
month = {Thu Mar 01 00:00:00 EST 2007}
}