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Title: Primate-specific evolution of an LDLR enhancer

Abstract

Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates. Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org.:
USDOE Director, Office of Science; National Institutes ofHealth
OSTI Identifier:
900785
Report Number(s):
LBNL-59217
R&D Project: GHPG6B; BnR: 400412000; TRN: US200711%%611
DOE Contract Number:
DE-AC02-05CH11231
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genome Biology; Journal Volume: 7; Journal Issue: 8; Related Information: Journal Publication Date: 08/02/2006
Country of Publication:
United States
Language:
English
Subject:
60; FUNCTIONALS; IN VITRO; IN VIVO; LIPOPROTEINS; PRIMATES

Citation Formats

Wang, Qian-Fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, Eisen, Michael B., Cheng, Jan-Fang, Rubin,Edward M., and Boffelli, Dario. Primate-specific evolution of an LDLR enhancer. United States: N. p., 2005. Web.
Wang, Qian-Fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, Eisen, Michael B., Cheng, Jan-Fang, Rubin,Edward M., & Boffelli, Dario. Primate-specific evolution of an LDLR enhancer. United States.
Wang, Qian-Fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, Eisen, Michael B., Cheng, Jan-Fang, Rubin,Edward M., and Boffelli, Dario. Thu . "Primate-specific evolution of an LDLR enhancer". United States. doi:. https://www.osti.gov/servlets/purl/900785.
@article{osti_900785,
title = {Primate-specific evolution of an LDLR enhancer},
author = {Wang, Qian-Fei and Prabhakar, Shyam and Wang, Qianben and Moses, Alan M. and Chanan, Sumita and Brown, Myles and Eisen, Michael B. and Cheng, Jan-Fang and Rubin,Edward M. and Boffelli, Dario},
abstractNote = {Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates. Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.},
doi = {},
journal = {Genome Biology},
number = 8,
volume = 7,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}