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Title: Bystander and Adaptive Responses in Tissue Models exposed to Low Radiation Doses

Abstract

The overall goal is characterization of 3D tissue models that can be used for investigation of the mechanisms underlying radiation-induced bystander effect at low doses (20 cGy or less) of low LET ionizing radiation, using a unique focused soft X-ray microprobe that had been upgraded to provide a range of focused soft X-ray energies, some sufficient to penetrate 3D models (Ref DE-FG02-01ER63236). The proposed studies will include an examination of whether the passage of a single electron track can trigger bystander responses in the 3D tissue models and, if so, whether the response is altered by increased or decreased levels of oxidative stress. Our existing multi-photon/confocal in-depth microscopy techniques will be used to develop assays for damage induced within intact 3D tissue models. The working hypothesis is that organization of cells into tissues, particularly involving more than one cell type, alters expression of the radiation-induced bystander effect compared to that seen in isolated single cell types in monolayer.

Authors:
Publication Date:
Research Org.:
Gray Cancer Institute
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
896797
Report Number(s):
DOE/ER/63633-1
DOE Contract Number:
FG02-03ER63633
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Radiation / Bystander effect / Tissue Models

Citation Formats

Kevin M. Prise. Bystander and Adaptive Responses in Tissue Models exposed to Low Radiation Doses. United States: N. p., 2007. Web.
Kevin M. Prise. Bystander and Adaptive Responses in Tissue Models exposed to Low Radiation Doses. United States.
Kevin M. Prise. Tue . "Bystander and Adaptive Responses in Tissue Models exposed to Low Radiation Doses". United States. doi:.
@article{osti_896797,
title = {Bystander and Adaptive Responses in Tissue Models exposed to Low Radiation Doses},
author = {Kevin M. Prise},
abstractNote = {The overall goal is characterization of 3D tissue models that can be used for investigation of the mechanisms underlying radiation-induced bystander effect at low doses (20 cGy or less) of low LET ionizing radiation, using a unique focused soft X-ray microprobe that had been upgraded to provide a range of focused soft X-ray energies, some sufficient to penetrate 3D models (Ref DE-FG02-01ER63236). The proposed studies will include an examination of whether the passage of a single electron track can trigger bystander responses in the 3D tissue models and, if so, whether the response is altered by increased or decreased levels of oxidative stress. Our existing multi-photon/confocal in-depth microscopy techniques will be used to develop assays for damage induced within intact 3D tissue models. The working hypothesis is that organization of cells into tissues, particularly involving more than one cell type, alters expression of the radiation-induced bystander effect compared to that seen in isolated single cell types in monolayer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 02 00:00:00 EST 2007},
month = {Tue Jan 02 00:00:00 EST 2007}
}

Technical Report:
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