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Title: A compact gamma camera for biological imaging

Abstract

A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm; spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator specially designed for {sup 125}I. Although the PSPMTs have insensitive areas at their edges and there is a physical gap, corrections for scintillation light collection at the junction between the two tubes results in a uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in-vivo imaging of small animals injected with iodinated compounds. We demonstrate an in-vivo application of this detector, particularly to SPECT, by imaging mice injected with approximately 10-15; spl mu/Ci of {sup 125}I.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Thomas Jefferson National Accelerator Facility, Newport News, VA
Sponsoring Org.:
USDOE - Office of Energy Research (ER)
OSTI Identifier:
894180
Report Number(s):
JLAB-PHY-06-541; DOE/ER/40150-5003
Journal ID: ISSN 0018-9499; IETNAE; TRN: US0700007
DOE Contract Number:
AC05-84ER40150
Resource Type:
Journal Article
Resource Relation:
Journal Name: IEEE Transactions on Nuclear Science; Journal Volume: 53; Journal Issue: 1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DESIGN; GAMMA CAMERAS; IN VIVO; MICE; RESOLUTION; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 125

Citation Formats

Bradley, E L, Cella, J, Majewski, S, Popov, V, Qian, Jianguo, Saha, M S, Smith, M F, Weisenberger, A G, and Welsh, R E. A compact gamma camera for biological imaging. United States: N. p., 2006. Web. doi:10.1109/TNS.2005.862977.
Bradley, E L, Cella, J, Majewski, S, Popov, V, Qian, Jianguo, Saha, M S, Smith, M F, Weisenberger, A G, & Welsh, R E. A compact gamma camera for biological imaging. United States. doi:10.1109/TNS.2005.862977.
Bradley, E L, Cella, J, Majewski, S, Popov, V, Qian, Jianguo, Saha, M S, Smith, M F, Weisenberger, A G, and Welsh, R E. Wed . "A compact gamma camera for biological imaging". United States. doi:10.1109/TNS.2005.862977. https://www.osti.gov/servlets/purl/894180.
@article{osti_894180,
title = {A compact gamma camera for biological imaging},
author = {Bradley, E L and Cella, J and Majewski, S and Popov, V and Qian, Jianguo and Saha, M S and Smith, M F and Weisenberger, A G and Welsh, R E},
abstractNote = {A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm; spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator specially designed for {sup 125}I. Although the PSPMTs have insensitive areas at their edges and there is a physical gap, corrections for scintillation light collection at the junction between the two tubes results in a uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in-vivo imaging of small animals injected with iodinated compounds. We demonstrate an in-vivo application of this detector, particularly to SPECT, by imaging mice injected with approximately 10-15; spl mu/Ci of {sup 125}I.},
doi = {10.1109/TNS.2005.862977},
journal = {IEEE Transactions on Nuclear Science},
number = 1,
volume = 53,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 2006},
month = {Wed Feb 01 00:00:00 EST 2006}
}