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Title: Do myoepithelial cells hold the key for breast tumorprogression?

Abstract

Mammary myoepithelial cells have been the foster child of breast cancer biology and have been largely ignored since they were considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge in stem cell biology and the cellular microenvironment has been increasing myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis if myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and if myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for cell cycle arrest, establishing epithelial cell polarity, and inhibiting migration and invasion. Based on these functions normal mammary myoepithelial cells have been called ''natural tumor suppressors''. However, during tumor progression myoepithelial cells seem to loose these properties and eventually they themselves diminish as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.

Authors:
;
Publication Date:
Research Org.:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org.:
USDOE Director. Office of Science. Office of Biological andEnvironmental Research; National Institutes of Health P50 CA89393-05 andCA94074-03, Department of Defense DAMD17-02-1-0692 and W81XWH-04-1-0452,American Cancer Society RSG-05-154-01-MGO
OSTI Identifier:
889622
Report Number(s):
LBNL-59752
R&D Project: 443180; BnR: KP1104010; TRN: US200704%%93
DOE Contract Number:  
DE-AC02-05CH11231
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Mammary Gland Biology and Neoplasis; Journal Volume: 10; Journal Issue: 3; Related Information: Journal Publication Date: 07/2005
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGY; CARCINOMAS; CELL CYCLE; HYPOTHESIS; MAMMARY GLANDS; NEOPLASMS; PHENOBARBITAL; STEM CELLS

Citation Formats

Polyak, Kornelia, and Hu, Min. Do myoepithelial cells hold the key for breast tumorprogression?. United States: N. p., 2005. Web.
Polyak, Kornelia, & Hu, Min. Do myoepithelial cells hold the key for breast tumorprogression?. United States.
Polyak, Kornelia, and Hu, Min. Fri . "Do myoepithelial cells hold the key for breast tumorprogression?". United States. doi:. https://www.osti.gov/servlets/purl/889622.
@article{osti_889622,
title = {Do myoepithelial cells hold the key for breast tumorprogression?},
author = {Polyak, Kornelia and Hu, Min},
abstractNote = {Mammary myoepithelial cells have been the foster child of breast cancer biology and have been largely ignored since they were considered to be less important for tumorigenesis than luminal epithelial cells from which most of breast carcinomas are thought to arise. In recent years as our knowledge in stem cell biology and the cellular microenvironment has been increasing myoepithelial cells are slowly starting to gain more attention. Emerging data raise the hypothesis if myoepithelial cells play a key role in breast tumor progression by regulating the in situ to invasive carcinoma transition and if myoepithelial cells are part of the mammary stem cell niche. Paracrine interactions between myoepithelial and luminal epithelial cells are known to be important for cell cycle arrest, establishing epithelial cell polarity, and inhibiting migration and invasion. Based on these functions normal mammary myoepithelial cells have been called ''natural tumor suppressors''. However, during tumor progression myoepithelial cells seem to loose these properties and eventually they themselves diminish as tumors become invasive. Better understanding of myoepithelial cell function and their role in tumor progression may lead to their exploitation for cancer therapeutic and preventative measures.},
doi = {},
journal = {Journal of Mammary Gland Biology and Neoplasis},
number = 3,
volume = 10,
place = {United States},
year = {Fri Nov 18 00:00:00 EST 2005},
month = {Fri Nov 18 00:00:00 EST 2005}
}