DNA Sliding Clamps: Just the Right Twist to Load onto DNA

Barsky, D; Venclovas, C

doi:10.1016/j.cub.2005.11.047

Title: DNA Sliding Clamps: Just the Right Twist to Load onto DNA

Journal Article · Mon Oct 24 00:00:00 EDT 2005 · Current Biology

DOI:https://doi.org/10.1016/j.cub.2005.11.047· OSTI ID:885400

Barsky, D; Venclovas, C

Two recent papers illuminate a long sought step in DNA sliding clamp loading. One paper reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while a second paper discovers that the clamp may assist this process by forming a right-handed helix upon opening.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 885400

Report Number(s):: UCRL-JRNL-216541; TRN: US200616%%547

Journal Information:: Current Biology, Vol. 15, Issue 24

Country of Publication:: United States

Language:: English

References (15)

Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp Kong, Xiang-Peng; Onrust, Rene; O'Donnell, Mike Cell, Vol. 69, Issue 3 https://doi.org/10.1016/0092-8674(92)90445-I	journal	May 1992
The PCNA–RFC Families of DNA Clamps and Clamp Loaders Majka, Jerzy; Burgers, Peter M. J. Progress in Nucleic Acid Research and Molecular Biology https://doi.org/10.1016/S0079-6603(04)78006-X	book	January 2004
Proliferating cell nuclear antigen (PCNA): a dancer with many partners Maga, G. Journal of Cell Science, Vol. 116, Issue 15 https://doi.org/10.1242/jcs.00653	journal	August 2003
CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork Johnson, Aaron; O'Donnell, Mike Annual Review of Biochemistry, Vol. 74, Issue 1 https://doi.org/10.1146/annurev.biochem.73.011303.073859	journal	June 2005
A Sliding-Clamp Toolbelt Binds High- and Low-Fidelity DNA Polymerases Simultaneously Indiani, Chiara; McInerney, Peter; Georgescu, Roxana Molecular Cell, Vol. 19, Issue 6 https://doi.org/10.1016/j.molcel.2005.08.011	journal	September 2005
Interaction of the sliding clamp with MutS, ligase, and DNA polymerase I Lopez de Saro, F. J.; O'Donnell, M. Proceedings of the National Academy of Sciences, Vol. 98, Issue 15 https://doi.org/10.1073/pnas.121009498	journal	July 2001
Pre-steady State Analysis of the Assembly of Wild Type and Mutant Circular Clamps of Escherichia coli DNA Polymerase III onto DNA Bertram, Jeffrey G.; Bloom, Linda B.; Turner, Jennifer Journal of Biological Chemistry, Vol. 273, Issue 38 https://doi.org/10.1074/jbc.273.38.24564	journal	September 1998
Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex Bowman, Gregory D.; O'Donnell, Mike; Kuriyan, John Nature, Vol. 429, Issue 6993 https://doi.org/10.1038/nature02585	journal	June 2004
Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis Miyata, T.; Suzuki, H.; Oyama, T. Proceedings of the National Academy of Sciences, Vol. 102, Issue 39 https://doi.org/10.1073/pnas.0506447102	journal	September 2005
Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen Kazmirski, S. L.; Zhao, Y.; Bowman, G. D. Proceedings of the National Academy of Sciences, Vol. 102, Issue 39 https://doi.org/10.1073/pnas.0506430102	journal	September 2005
The internal workings of a DNA polymerase clamp-loading machine Turner, J. The EMBO Journal, Vol. 18, Issue 3 https://doi.org/10.1093/emboj/18.3.771	journal	February 1999
ATP Utilization by Yeast Replication Factor C Gomes, Xavier V.; Schmidt, Sonja L. Gary; Burgers, Peter M. J. Journal of Biological Chemistry, Vol. 276, Issue 37 https://doi.org/10.1074/jbc.M011743200	journal	September 2001
Distinct roles for ATP binding and hydrolysis at individual subunits of an archaeal clamp loader Seybert, Anja; Wigley, Dale B. The EMBO Journal, Vol. 23, Issue 6 https://doi.org/10.1038/sj.emboj.7600130	journal	March 2004
Ordered ATP Hydrolysis in the γ Complex Clamp Loader AAA+ Machine Johnson, Aaron; O'Donnell, Mike Journal of Biological Chemistry, Vol. 278, Issue 16 https://doi.org/10.1074/jbc.M212708200	journal	April 2003
Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III Jeruzalmi, David; O'Donnell, Mike; Kuriyan, John Cell, Vol. 106, Issue 4 https://doi.org/10.1016/S0092-8674(01)00463-9	journal	August 2001

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