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Title: Method And Apparatus For Production Of Bi-213 From The Activity Ac-225 Source

Abstract

A method and apparatus for isolating and purifying a .sup.213 Bi radioactive isotope from an .sup.225 Ac source using a primary column and a primary sorbent which preferentially retains .sup.225 Ac over .sup.213 Bi when exposed to a compatible solvent in combination with a secondary column having a secondary sorbent which retains .sup.213 Bi when exposed to a mixture of the compatible solvent and .sup.213 Bi. A "compatible solvent" is a solvent which will preferentially remove .sup.213 Bi radioactive isotopes from a primary sorbent without removing .sup.225 Ac radioactive isotopes, and then allow .sup.213 Bi radioactive isotopes removed from the primary sorbent to be retained on a secondary sorbent, without having to dilute or otherwise chemically or physically modify the compatible solvent in between exposure to the primary and secondary sorbents.

Inventors:
 [1];  [2]
  1. (West Richland, WA)
  2. (Richland, WA)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
OSTI Identifier:
880393
Patent Number(s):
US 6972414
Application Number:
10/808090
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Egorov, Oleg B., and O'Hara, Matthew J.. Method And Apparatus For Production Of Bi-213 From The Activity Ac-225 Source. United States: N. p., 2005. Web.
Egorov, Oleg B., & O'Hara, Matthew J.. Method And Apparatus For Production Of Bi-213 From The Activity Ac-225 Source. United States.
Egorov, Oleg B., and O'Hara, Matthew J.. Tue . "Method And Apparatus For Production Of Bi-213 From The Activity Ac-225 Source". United States. doi:. https://www.osti.gov/servlets/purl/880393.
@article{osti_880393,
title = {Method And Apparatus For Production Of Bi-213 From The Activity Ac-225 Source},
author = {Egorov, Oleg B. and O'Hara, Matthew J.},
abstractNote = {A method and apparatus for isolating and purifying a .sup.213 Bi radioactive isotope from an .sup.225 Ac source using a primary column and a primary sorbent which preferentially retains .sup.225 Ac over .sup.213 Bi when exposed to a compatible solvent in combination with a secondary column having a secondary sorbent which retains .sup.213 Bi when exposed to a mixture of the compatible solvent and .sup.213 Bi. A "compatible solvent" is a solvent which will preferentially remove .sup.213 Bi radioactive isotopes from a primary sorbent without removing .sup.225 Ac radioactive isotopes, and then allow .sup.213 Bi radioactive isotopes removed from the primary sorbent to be retained on a secondary sorbent, without having to dilute or otherwise chemically or physically modify the compatible solvent in between exposure to the primary and secondary sorbents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 06 00:00:00 EST 2005},
month = {Tue Dec 06 00:00:00 EST 2005}
}

Patent:

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  • A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed. 7 figs.
  • A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.
  • Among the very limited number of potential alpha emitters, {sup 213}Bi has recently entered phase I of human trial against lung tumor in mice has shown total eradication of implanted tumors. Bismuth-213 decays with a t{sup {1/2}} of 45.6 min and emits an 8.4-MeV alpha particle 97.8% of the time. The decay of {sup 213}Bi follows with the emission of rather low abundance gamma rays: 440 keV (16.5%) and 1566 keV (2%). Carrier-free {sup 213}Bi is available from the {sup 225}Ac/{sup 213}Bi generator system with {sup 225}Ac (t{sub {1/2}} = 10 days) being the daughter of 7340-yr {sup 229}Th, which,more » in turn, is the decay daughter of long-lived {sup 233}U. Uranium-233 was produced at Oak Ridge National Laboratory (ORNL) in the 1960s and 1970s as part of the molten salt breeder reactor program. Thorium-229 was separated from a waste stream of {sup 233}U processing that had been stored in a number of waste tanks at ORNL. Our current inventory is {approximately}65 mCi of low-specific-activity ({approximately}0.4%) {sup 229}Th.« less
  • Method and apparatus are described for the pollution-free generation of electrical power from carbonaceous fuels. Molten lead is electrochemically oxidized to produce lead oxide and electricity in a single integrated cell in which the resulting lead oxide is simultaneously converted back to lead metal by carbothermic reduction with a carbonaceous fuel. The entire process is carried out in a single cell using a molten carbonate as electrolyte in a temperature range of 500/sup 0/ to 900/sup 0/C. The entire cycle thus consumes only carbon and oxygen and produces electricity. It is found that, by thus coupling the electrochemical cell andmore » the thermochemical regeneration system, the resulting integrated carbon--lead--air cell will maintain a voltage well above that provided by a simple lead--air cell, and indeed approach that of a hypothetical carbon--air cell. 2 figures.« less
  • A method and apparatus for forming patterned coatings of thin film, non-polymerizable compounds on a substrate. A mixture of the non-polymerizable compound and a liquid carrier is pumped into the interior of a heated evaporation box having an internal temperature sufficient to convert substantially all of the non-polymerizable compound and liquid carrier to a gaseous form. The non-polymerizable compound and liquid carrier are then removed from the evaporation box via exit slit in the evaporation box. Adjacent to the exit slit, and maintained in a vacuum, is a first substrate upon which the non-polymerizable compound condenses. The first substrate ismore » in motion, for example on a web roller, thereby allowing a continuous coating of the non-polymerizable compound to be applied to the first substrate. Once the non-polymerizable compound is applied to one side of the first substrate, an energy source is then directed toward the opposite side of the first substrate. In this manner, a portion of the non-polymerizable compound is removed from the first substrate. A second substrate is then provided adjacent to the first substrate, and the non-polymerizable compound is thereby transferred from the first substrate onto the second substrate. By repeatedly transferring portions of the non-polymerizable material from the first substrate to the second substrate in this manner, the thin film, non-polymerizable materials can be formed onto the second substrate in a predetermined pattern, and in a continuous and highly efficient process.« less