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Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides

Patent ·
OSTI ID:880175
 [1];  [1];  [2];  [1]
  1. Germantown, MD
  2. Montgomery Village, MD
+ Show Author Affiliations
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
Research Organization:
Fidelity Systems, Inc. (Gaithersburg, MD)
DOE Contract Number:
FG02-98ER82577
Assignee:
Fidelity Systems, Inc. (Gaithersburg, MD)
Patent Number(s):
US 6548251
Application Number:
10/655804
OSTI ID:
880175
Country of Publication:
United States
Language:
English

References (12)

Synthesis of functionally modified oligonucleotides from methoxyoxalamido precursors journal May 1996
Synthesis of Suitably-Protected Phosphoramidites of 2′-Fluoro-2′-Deoxyguanosine and 2′-Amino-2′-Deoxyguanosine for Incorporation Into Oligoribonucleotides journal August 1992
Synthesis of functionally tethered oligodeoxynucleotides by the convertible nucleoside approach journal November 1990
Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries journal December 1994
Synthesis of oligonucleotides containing 2′-azido- and 2′-amino-2′-deoxyuridine using phosphotriester chemistry journal May 1996
Synthesis and characterization of imidazoyl-linked synthons and 3'-conjugated thymidine derivatives journal August 1993
Drug Leads from Combinatorial Phosphodiester Libraries journal October 1995
Synthesis of 2′–modified nucleotides and their incorporation into hammerhead ribozymes journal January 1995
Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives journal January 1991
Sequencing Oligonucleotides by Exonuclease Digestion and Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry journal June 1996
Aminolysis of 2′-Deoxyinosine Aryl Ethers: Nucleoside Model Studies for the Synthesis of Functionally Tethered Oligonucleotides journal December 1992
Engineering tethered DNA molecules by the convertible nucleoside approach journal January 1991

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