Method for calibrating mass spectrometers

Patent · Tue Dec 24 00:00:00 EST 2002

OSTI ID:874962

Anderson, Gordon A ^[1]; Brands, Michael D ^[2]; Bruce, James E ^[3]; Pasa-Tolic, Ljiljana ^[2]; Smith, Richard D ^[2]

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1. Benton City, WA
2. Richland, WA
3. Schwenksville, PA

A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Richland, WA)
• Patent Number(s): 6,498,340
• OSTI ID: 874962
• Country of Publication: United States
• Language: English

Related Subjects

method
calibrating
mass
spectrometers
spectra
generated
spectrometer
calibrated
shifting
parameters
masses
manner
reconciles
signal
equal
differing
charge
reconciling
differences
values
consistent
standards
allowing
generation
highly
accurate
instrument
mass spectrometer
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