skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Patent ·
OSTI ID:874857
 [1]
  1. Knoxville, TN
+ Show Author Affiliations

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
DOE Contract Number:
AC05-84OR21400
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
US 6475363
OSTI ID:
874857
Country of Publication:
United States
Language:
English

References (11)

Integrated Electrophoresis Systems for Biochemical Analyss conference June 1994
High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device journal September 1994
Planar chips technology for miniaturization and integration of separation techniques into monitoring systems journal February 1992
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal April 1994
Synchronized cyclic capillary electrophores—a novel approach to ion separations in solution journal October 1993
High-Speed Separations on a Microchip journal April 1994
Electrically Driven Separations on a Microship conference June 1994
Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip journal October 1994
Towards miniaturized electrophoresis and chemical analysis systems on silicon: an alternative to chemical sensors journal January 1993
A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE) journal June 1994
Open Channel Electrochromatography on a Microchip journal July 1994

Similar Records

Related Subjects

apparatus
method
performing
microfluidic
manipulations
chemical
analysis
synthesis
microchip
laboratory
provide
fluid
variety
applications
including
sample
injection
separations
fabricated
standard
photolithographic
procedures
wet
etching
substrate
cover
plate
joined
direct
bonding
capillary
electrophoresis
electrochromatography
performed
channels
formed
analytes
loaded
four-way
intersection
electrokinetically
pumping
analyte
followed
switching
potentials
force
plug
separation
channel
wet etching
microfluidic manipulations
performing microfluidic
including sample
microchip chemical
microchip laboratory
fluid manipulations
provide fluid
/204/