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Title: Cell density signal protein suitable for treatment of connective tissue injuries and defects

Abstract

Identification, isolation and partial sequencing of a cell density protein produced by fibroblastic cells. The cell density signal protein comprising a 14 amino acid peptide or a fragment, variant, mutant or analog thereof, the deduced cDNA sequence from the 14 amino acid peptide, a recombinant protein, protein and peptide-specific antibodies, and the use of the peptide and peptide-specific antibodies as therapeutic agents for regulation of cell differentiation and proliferation. A method for treatment and repair of connective tissue and tendon injuries, collagen deficiency, and connective tissue defects.

Inventors:
 [1]
  1. Oakland, CA
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
874652
Patent Number(s):
US 6433136
Application Number:
09/215184
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
cell; density; signal; protein; treatment; connective; tissue; injuries; defects; identification; isolation; partial; sequencing; produced; fibroblastic; cells; comprising; 14; amino; acid; peptide; fragment; variant; mutant; analog; deduced; cdna; sequence; recombinant; peptide-specific; antibodies; therapeutic; agents; regulation; differentiation; proliferation; method; repair; tendon; collagen; deficiency; amino acid; dna sequence; /530/

Citation Formats

Schwarz, Richard I. Cell density signal protein suitable for treatment of connective tissue injuries and defects. United States: N. p., 2002. Web.
Schwarz, Richard I. Cell density signal protein suitable for treatment of connective tissue injuries and defects. United States.
Schwarz, Richard I. Tue . "Cell density signal protein suitable for treatment of connective tissue injuries and defects". United States. https://www.osti.gov/servlets/purl/874652.
@article{osti_874652,
title = {Cell density signal protein suitable for treatment of connective tissue injuries and defects},
author = {Schwarz, Richard I},
abstractNote = {Identification, isolation and partial sequencing of a cell density protein produced by fibroblastic cells. The cell density signal protein comprising a 14 amino acid peptide or a fragment, variant, mutant or analog thereof, the deduced cDNA sequence from the 14 amino acid peptide, a recombinant protein, protein and peptide-specific antibodies, and the use of the peptide and peptide-specific antibodies as therapeutic agents for regulation of cell differentiation and proliferation. A method for treatment and repair of connective tissue and tendon injuries, collagen deficiency, and connective tissue defects.},
doi = {},
url = {https://www.osti.gov/biblio/874652}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

Role of procollagen mRNA levels in controlling the rate of procollagen synthesis.
journal, February 1983


Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.
journal, March 1988


Cell-to-cell signaling in the regulation of procollagen expression in primary avian tendon cells
journal, September 1991


Dependence of the differentiated state on the cellular environment: modulation of collagen synthesis in tendon cells.
journal, October 1977


Evidence supporting the role of a proteinaceous, loosely bound extracellular molecule in the cell density signaling between tendon cells
journal, November 1992


Modeling tendon morphogenesis in vivo based on cell density signaling in cell culture
journal, November 1996