Invasive cleavage of nucleic acids
Patent
·
OSTI ID:874241
- Madison, WI
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
- Research Organization:
- Third Wave Technologies, Inc., Madison, WI (United States)
- DOE Contract Number:
- FG02-94ER81891
- Assignee:
- Third Wave Technologies, Inc. (Madison, WI)
- Patent Number(s):
- US 6348314
- OSTI ID:
- 874241
- Country of Publication:
- United States
- Language:
- English
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invasive
cleavage
nucleic
acids
relates
means
detection
characterization
acid
sequences
variations
methods
forming
structure
target
sequence
cleaving
site-specific
manner
structure-specific
nuclease
activity
variety
enzymes
cleave
target-dependent
indicating
presence
specific
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acid sequence
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cleavage
nucleic
acids
relates
means
detection
characterization
acid
sequences
variations
methods
forming
structure
target
sequence
cleaving
site-specific
manner
structure-specific
nuclease
activity
variety
enzymes
cleave
target-dependent
indicating
presence
specific
nucleic acid
acid sequence
specific nucleic
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