Fluoralkenyl nortropanes

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874224

Goodman, Mark M ^[1]; Chen, Ping ^[2]

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1. Atlanta, GA
2. Indianapolis, IN

Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• DOE Contract Number: FG02-97ER62367
• Assignee: Emory University (Atlanta, GA)
• Patent Number(s): US 6344179
• Application Number: 09/553795
• OSTI ID: 874224
• Country of Publication: United States
• Language: English

Related Subjects

fluoralkenyl
nortropanes
provided
compounds
following
formula
str1
c2-c6
mono-
multi-unsaturated
hydrocarbon
ethylene
acetylene
allene
18
19
halogen
bind
dopamine
transporter
affinity
selectivity
useful
diagnostic
therapeutic
agents
diseases
associated
dysfunction
radiolabeled
imaging
visualizing
location
density
pet
pet imaging
saturated hydrocarbon
unsaturated hydrocarbon
/424/999/