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Title: Device to improve detection in electro-chromatography

Abstract

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated, thereby providing for a significant improvement in resolution and more accurate detection and analysis.

Inventors:
 [1];  [1];  [2]
  1. Livermore, CA
  2. Fremont, CA
Publication Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
874221
Patent Number(s):
US 6344145
Assignee:
Sandia Corporation (Livermore, CA)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
device; improve; detection; electro-chromatography; apparatus; method; improving; resolution; non-pressure; driven; capillary; chromatographic; systems; electrochromatography; cec; reducing; cross-sectional; packed; column; means; contiguous; outlet; sectional; times; phenomenon; band; broadening; transition; region; individual; components; mixture; analyzed; eliminated; providing; significant; improvement; accurate; analysis; capillary column; /210/204/

Citation Formats

Garguilo, Michael G, Paul, Phillip H, and Rakestraw, David J. Device to improve detection in electro-chromatography. United States: N. p., 2002. Web.
Garguilo, Michael G, Paul, Phillip H, & Rakestraw, David J. Device to improve detection in electro-chromatography. United States.
Garguilo, Michael G, Paul, Phillip H, and Rakestraw, David J. Tue . "Device to improve detection in electro-chromatography". United States. https://www.osti.gov/servlets/purl/874221.
@article{osti_874221,
title = {Device to improve detection in electro-chromatography},
author = {Garguilo, Michael G and Paul, Phillip H and Rakestraw, David J},
abstractNote = {Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated, thereby providing for a significant improvement in resolution and more accurate detection and analysis.},
doi = {},
url = {https://www.osti.gov/biblio/874221}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

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