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Title: Inhibition of selectin binding

Patent ·
OSTI ID:874039
 [1];  [2];  [3];  [2]
  1. Rodeo, CA
  2. Albany, CA
  3. New Delhi, IN
+ Show Author Affiliations

This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6299897
Application Number:
09/440880
OSTI ID:
874039
Country of Publication:
United States
Language:
English

References (9)

Preparation and Characterization of Polymerized Liposomes journal June 1985
Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly journal July 1993
Polymerized liposomes containing C-glycosides of sialic acid: potent inhibitors of influenza virus in vitro infectivity journal February 1993
Molecular assemblies of functionalized polydiacetylenes journal January 1995
Studies on carbohydrate-binding proteins using liposome-based systems—I. Preparation of neoglycoprotein-conjugated liposomes and the feasibility of their use as drug-targeting devices journal January 1992
[6] Neoglycoprotein-liposome and lectin-liposome conjugates as tools for carbohydrate recognition research book January 1994
Polydiacetylene monolayers functionalized with amino acids journal October 1992
Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury journal December 1995
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. journal December 1991

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Related Subjects

inhibition
selectin
binding
provides
compositions
inhibiting
cells
expressing
p-
l-selectin
surface
corresponding
ligand
covalently
crosslinked
lipid
composition
prepared
saccharides
acidic
separate
lipids
interposed
inhibit
achieved
effective
oligosaccharide
concentration
10
fold
below
free
saccharide
selectins
involved
recruiting
sites
injury
scan
palliate
inflammatory
immunological
conditions
recruiting cells
provides compositions
selectin binding
separate lipids
oligosaccharide concentration
expressing p-
fold below
free saccharide
lipid composition
effective oligosaccharide
covalently crosslinked
crosslinked lipid
corresponding ligand
immunological conditions
inhibit binding
/424/514/999/