System and method for chromatography and electrophoresis using circular optical scanning

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:874025

Balch, Joseph W ^[1]; Brewer, Laurence R ^[2]; Davidson, James C ^[1]; Kimbrough, Joseph R ^[3]

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1. Livermore, CA
2. Oakland, CA
3. Pleasanton, CA

A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels. As a third step, the scanning device is passed over the analysis channels at dynamically varying distances from a centerpoint of the scanning device. As a fourth step, molecular samples are loaded into the analysis channels with a robot.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 6296749
• OSTI ID: 874025
• Country of Publication: United States
• Language: English

Related Subjects

method
chromatography
electrophoresis
circular
optical
scanning
disclosed
rectangular
microchannel
plates
radial
set
analysis
channels
insertion
molecular
samples
devices
repeatedly
pass
direction
predetermined
rotational
velocity
radius
dynamically
varied
monitor
sample
various
positions
channel
loading
robots
input
built
substrate
disposed
non-parallel
angle
respect
step
accesses
plate
passes
device
third
passed
varying
distances
centerpoint
fourth
loaded
robot
channel plate
third step
microchannel plate
microchannel plates
optical scanning
circular optical
rotational velocity
scanning device
various positions
dynamically varied
/204/436/250/356/