System and method for chromatography and electrophoresis using circular optical scanning

Patent · 31 December 2000

OSTI ID:874025

Balch, Joseph W ^[1]; Brewer, Laurence R ^[2]; Davidson, James C ^[1]; Kimbrough, Joseph R ^[3]

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1. Livermore, CA
2. Oakland, CA
3. Pleasanton, CA

A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels. As a third step, the scanning device is passed over the analysis channels at dynamically varying distances from a centerpoint of the scanning device. As a fourth step, molecular samples are loaded into the analysis channels with a robot.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 6296749
• OSTI ID: 874025
• Country of Publication: United States
• Language: English

Related Subjects

/204/436/250/356/
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electrophoresis
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third
third step
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