Preparation of 2-hydroxy-5-oxoproline and analogs thereof

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:873985

Martinez, Rodolfo A ^[1]; Unkefer, Pat J ^[2]

---

1. Santa Fe, NM
2. Los Alamos, NM

The compound 2-hydroxy-5-oxoproline and analogs thereof may be used to produce an increase in carbon dioxide fixation, growth, dry weight, nutritional value (proteins and amino acids), nodulation and nitrogen fixation and photosynthetically derived chemical energy when applied to plants through their roots and/or through their foliar portions. The present invention includes an essentially quantitative chemical synthesis for this compound which is performed in a single step reaction of Fremy's Salt (potassium nitrosodisulphonate) with either glutamine or 2-pyrrolidone-5-carboxylic acid. Fremy's salt (potassium nitrosodisulphonate) is available commercially, or can be readily synthesized.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• DOE Contract Number: W-7405-ENG-36
• Assignee: Regents of University of California (Los Alamos, NM)
• Patent Number(s): US 6288240
• OSTI ID: 873985
• Country of Publication: United States
• Language: English

Related Subjects

preparation
2-hydroxy-5-oxoproline
analogs
compound
produce
increase
carbon
dioxide
fixation
growth
dry
weight
nutritional
value
proteins
amino
acids
nodulation
nitrogen
photosynthetically
derived
chemical
energy
applied
plants
roots
foliar
portions
essentially
quantitative
synthesis
performed
single
step
reaction
fremy
salt
potassium
nitrosodisulphonate
glutamine
2-pyrrolidone-5-carboxylic
acid
available
commercially
readily
synthesized
chemical synthesis
dry weight
nitrogen fixation
single step
chemical energy
amino acid
carbon dioxide
carboxylic acid
amino acids
step reaction
/999/