skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Purine inhibitors of protein kinases, G proteins and polymerases

Patent ·
OSTI ID:873825
 [1];  [2];  [3];  [4]
  1. Berkeley, CA
  2. Oakland, CA
  3. Moraga, CA
  4. Roscoff, FR
+ Show Author Affiliations

The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents of University of California (Oakland, CA); Centre National de la Recherche Scientifique (Paris, FR)
Patent Number(s):
US 6255485
Application Number:
09/130255
OSTI ID:
873825
Country of Publication:
United States
Language:
English

References (6)

Combinatorial synthesis of 2,9-substituted purines journal February 1997
Inhibition of Cyclin-Dependent Kinases by Purine Analogues journal September 1994
Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors:  Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds journal February 1997
A Structure-Based Library Approach to Kinase Inhibitors journal January 1996
Synthesis and activity of 2,6,9-trisubstituted purines journal November 1997
Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine journal January 1997

Similar Records

Purine inhibitors of protein kinases, G proteins and polymerases
Patent · Tue Oct 12 00:00:00 EDT 2004 · OSTI ID:873825
+1 more
Methods Of Using Chemical Libraries To Search For New Kinase Inhibitors
Patent · Tue Jun 03 00:00:00 EDT 2003 · OSTI ID:873825
Purine Inhibitors Of Protein Kinases, G Proteins And Polymerases
Patent · Tue Sep 09 00:00:00 EDT 2003 · OSTI ID:873825

Related Subjects

purine
inhibitors
protein
kinases
proteins
polymerases
relates
analogs
inhibit
alia
g-proteins
addition
methods
cellular
processes
treat
proliferative
diseases
protein kinase
protein kinases
/999/