Purine inhibitors of protein kinases, G proteins and polymerases
Abstract
The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.
- Inventors:
-
- Berkeley, CA
- Oakland, CA
- Moraga, CA
- Roscoff, FR
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 873825
- Patent Number(s):
- US 6255485
- Application Number:
- 09/130255
- Assignee:
- Regents of University of California (Oakland, CA); Centre National de la Recherche Scientifique (Paris, FR)
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- purine; inhibitors; protein; kinases; proteins; polymerases; relates; analogs; inhibit; alia; g-proteins; addition; methods; cellular; processes; treat; proliferative; diseases; protein kinase; protein kinases; /999/
Citation Formats
Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States: N. p., 2001.
Web.
Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, & Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States.
Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Mon .
"Purine inhibitors of protein kinases, G proteins and polymerases". United States. https://www.osti.gov/servlets/purl/873825.
@article{osti_873825,
title = {Purine inhibitors of protein kinases, G proteins and polymerases},
author = {Gray, Nathanael S and Schultz, Peter and Kim, Sung-Hou and Meijer, Laurent},
abstractNote = {The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.},
doi = {},
url = {https://www.osti.gov/biblio/873825},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}
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Works referenced in this record:
Combinatorial synthesis of 2,9-substituted purines
journal, February 1997
- Gray, Nathanael S.; Kwon, Soojin; Schultz, Peter G.
- Tetrahedron Letters, Vol. 38, Issue 7
Inhibition of Cyclin-Dependent Kinases by Purine Analogues
journal, September 1994
- Vesely, Jaroslav; Havlicek, Libor; Strnad, Miroslav
- European Journal of Biochemistry, Vol. 224, Issue 2
Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds
journal, February 1997
- Havlíček, Libor; Hanuš, Jan; Veselý, Jaroslav
- Journal of Medicinal Chemistry, Vol. 40, Issue 4
A Structure-Based Library Approach to Kinase Inhibitors
journal, January 1996
- Norman, Thea C.; Gray, Nathanael S.; Koh, John T.
- Journal of the American Chemical Society, Vol. 118, Issue 31
Synthesis and activity of 2,6,9-trisubstituted purines
journal, November 1997
- Schow, Steven R.; Mackman, Richard L.; Blum, Cheri L.
- Bioorganic & Medicinal Chemistry Letters, Vol. 7, Issue 21
Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine
journal, January 1997
- Azevedo, Walter Filgueira; Leclerc, Sophie; Meijer, Laurent
- European Journal of Biochemistry, Vol. 243, Issue 1-2