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Title: Microbial methods of reducing technetium

Patent ·
OSTI ID:873672
 [1];  [2];  [1];  [3];  [1];  [1]
  1. Richland, WA
  2. Greybull, WY
  3. Benton City, WA
+ Show Author Affiliations

The present invention is directed toward a method for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanelia putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
US 6218171
Application Number:
09/398,834
OSTI ID:
873672
Country of Publication:
United States
Language:
English

References (7)

The biomedical chemistry of technetium and rhenium journal January 1998
Technetium-99m labelling of bis-oxime ligands journal May 1994
Technetium reduction and precipitation by sulfate‐reducing bacteria journal January 1998
Technetium Sources and Behavior in the Environment1 journal January 1979
Dissimilatory Metal Reduction journal October 1993
Methods of Preparation of Some Carrier-Free Radioisotopes Involving Sorption on Alumina report May 1958
Bioaccumulation and Chemical Modification of Tc by Soil Bacteria journal January 1989

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Related Subjects

microbial
methods
reducing
technetium
directed
method
reduction
compound
form
compounds
value
medical
imaging
combined
mixture
non-growing
cells
contain
technetium-reducing
enzyme
stabilizing
agent
electron
donor
saline
solution
anaerobic
conditions
substantially
free
inorganic
products
resulting
product
tc
oxidation
partially
controlled
discovered
microorganisms
shewanella
alga
strain
bry
shewanelia
putrifacians
cn-32
systems
mono
nuclear
polynuclear
reduced
species
depending
saline solution
resulting product
substantially free
reducing agent
anaerobic conditions
electron donor
stabilizing agent
microbial reduction
medical imaging
technetium compound
microbial cell
aerobic conditions
/435/999/