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Title: Oncoprotein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
 [1];  [1];  [2]
  1. (San Diego, CA)
  2. (La Jolla, CA)
Publication Date:
Research Org.:
University of California
OSTI Identifier:
873579
Patent Number(s):
US 6193965
Application Number:
09/452,370
Assignee:
Regents of University of California (Oakland, CA) OAK
DOE Contract Number:  
FG03-86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
oncoprotein; kinase; isolated; polypeptide; jnk; characterized; molecular; weight; 46; kd; 55; determined; reducing; sds-page; serine; theonine; activity; phosphorylating; c-jun; n-terminal; activation; domain; polynucleotide; sequences; method; detection; provided; phosphorylates; affects; expression; ap-1; sites; phosphorylates c-jun; ap-1 sites; protein kinase; reducing sds-page; kinase activity; jnk phosphorylates; activation domain; nucleotide sequences; nucleotide sequence; n-terminal activation; c-jun n-terminal; molecular weight; isolated polypeptide; polynucleotide sequences; theonine kinase; /424/514/

Citation Formats

Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein kinase. United States: N. p., 2001. Web.
Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein kinase. United States.
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue . "Oncoprotein kinase". United States. https://www.osti.gov/servlets/purl/873579.
@article{osti_873579,
title = {Oncoprotein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 27 00:00:00 EST 2001},
month = {Tue Feb 27 00:00:00 EST 2001}
}

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