Glutathione-S-conjugate transport in plants

Rea, Philip A; Lu, Yu-Ping; Li, Ze-Sheng

Title: Glutathione-S-conjugate transport in plants

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873465

Rea, Philip A ^[1]; Lu, Yu-Ping ^[2]; Li, Ze-Sheng ^[3]

Ardmore, PA
Havertown, PA
Prospect Park, PA

The invention includes an isolated DNA encoding a plant GS-X pump polypeptide and an isolated preparation of a plant GS-X pump polypeptide. Also included is an isolated preparation of a nucleic acid which is antisense in orientation to a portion or all of a plant GS-X pump gene. The invention also includes a cells, vectors and transgenic plants having an isolated DNA encoding a plant GS-X pump and methods of use thereof. In addition, the invention relates to plant GS-X pump promoter sequences and the uses thereof.

View Patent

Cite

Export

Save

Research Organization:: Univ. of Pennsylvania, Philadelphia, PA (United States)

DOE Contract Number:: FG02-91ER20055

Assignee:: Trustees of University of Pennsylvania ()

Patent Number(s):: US 6166290

OSTI ID:: 873465

Country of Publication:: United States

Language:: English

References (72)

An improved procedure for transformingArabidopsis thaliana (Landsbergerecta) root explant Huang, Hai; Mā, Hong Plant Molecular Biology Reporter, Vol. 10, Issue 4 https://doi.org/10.1007/BF02668914	journal	November 1992
Oxidative stress in plants Inzé, Dirk; Montagu, Marc Van Current Opinion in Biotechnology, Vol. 6, Issue 2 https://doi.org/10.1016/0958-1669(95)80024-7	journal	January 1995
1-Chloro-2,4-Dinitrobenzene-Elicited Increase in Vacuolar Glutathione-S-Conjugate Transport Activity Li, Z. S.; Zhen, R. G.; Rea, P. A. Plant Physiology, Vol. 109, Issue 1 https://doi.org/10.1104/pp.109.1.177	journal	September 1995
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. Leier, I.; Jedlitschky, G.; Buchholz, U. Journal of Biological Chemistry, Vol. 269, Issue 45 https://doi.org/10.1016/S0021-9258(18)46856-1	journal	November 1994
Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Teeter, L. D.; Becker, F. F.; Chisari, F. V. Molecular and Cellular Biology, Vol. 10, Issue 11 https://doi.org/10.1128/MCB.10.11.5728	journal	November 1990
Promises and Prospects of Phytoremediation Cunningham, S. D.; Ow, D. W. Plant Physiology, Vol. 110, Issue 3 https://doi.org/10.1104/pp.110.3.715	journal	March 1996
A Cadmium-Sensitive, Glutathione-Deficient Mutant of Arabidopsis thaliana Howden, R.; Andersen, C. R.; Goldsbrough, P. B. Plant Physiology, Vol. 107, Issue 4 https://doi.org/10.1104/pp.107.4.1067	journal	April 1995
Stability of Zinc Complexes with Glutathione and Oxidized Glutathione ¹ Li, Norman C.; Gawron, Oscar; Bascuas, Gloria Journal of the American Chemical Society, Vol. 76, Issue 1 https://doi.org/10.1021/ja01630a058	journal	January 1954
Antisense genes in plants: an overview van der Krol, Alexander R.; Mol, Joseph N. M.; Stuitje, Antoine R. Gene, Vol. 72, Issue 1-2 https://doi.org/10.1016/0378-1119(88)90126-6	journal	December 1988
Molecular characterization of corn glutathione S-transferase isozymes involved in herbicide detoxication Timmerman, Kurt P. Physiologia Plantarum, Vol. 77, Issue 3 https://doi.org/10.1111/j.1399-3054.1989.tb05668.x	journal	November 1989
Agrobacterium tumefaciens-mediated transformation of Arabidopsis thaliana root explants by using kanamycin selection Valvekens, D.; Montagu, M. V.; Lijsebettens, M. V. Proceedings of the National Academy of Sciences, Vol. 85, Issue 15 https://doi.org/10.1073/pnas.85.15.5536	journal	August 1988
Cadmium-Sensitive Mutants of Arabidopsis thaliana Howden, Ross; Cobbett, Christopher S. Plant Physiology, Vol. 100, Issue 1 https://doi.org/10.1104/pp.100.1.100	journal	September 1992
A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. Szczypka, M. S.; Wemmie, J. A.; Moye-Rowley, W. S. Journal of Biological Chemistry, Vol. 269, Issue 36 https://doi.org/10.1016/S0021-9258(17)31723-4	journal	September 1994
Binary Agrobacterium vectors for plant transformation Bevan, Michael Nucleic Acids Research, Vol. 12, Issue 22 https://doi.org/10.1093/nar/12.22.8711	journal	January 1984
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Muller, M.; Meijer, C.; Zaman, G. J. Proceedings of the National Academy of Sciences, Vol. 91, Issue 26 https://doi.org/10.1073/pnas.91.26.13033	journal	December 1994
Yeast multidrug resistance: The PDR network Balzi, Elisabetta; Goffeau, André Journal of Bioenergetics and Biomembranes, Vol. 27, Issue 1 https://doi.org/10.1007/BF02110333	journal	February 1995
parB: an auxin-regulated gene encoding glutathione S-transferase. Takahashi, Y.; Nagata, T. Proceedings of the National Academy of Sciences, Vol. 89, Issue 1 https://doi.org/10.1073/pnas.89.1.56	journal	January 1992
High Purity Preparations of Higher Plant Vacuolar H+-ATPase Reveal Additional Subunits Parry, R. V.; Turner, J. C.; Rea, P. A. Journal of Biological Chemistry, Vol. 264, Issue 33 https://doi.org/10.1016/S0021-9258(19)47213-X	journal	November 1989
Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia Jansen, Peter L. M.; Groothuis, Geny M. M.; Peters, Wilbert H. M. Hepatology, Vol. 7, Issue 1 https://doi.org/10.1002/hep.1840070116	journal	January 1987
Tonoplast Adenosine Triphosphatase and Inorganic Pyrophosphatase Rea, Philip A.; Turner, Janice C. Methods in Plant Biochemistry https://doi.org/10.1016/B978-0-12-461013-2.50035-6	book	January 1990
MRP subfamily ABC transporters from plants and yeast Rea, Philip A. Journal of Experimental Botany, Vol. 50, Issue Special_Issue https://doi.org/10.1093/jxb/50.Special_Issue.895	journal	June 1999
Coordinated Induction of / Pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells Ishikawa, Toshihisa; Bao, Jia-Ju; Yamane, Yoshiaki Journal of Biological Chemistry, Vol. 271, Issue 25 https://doi.org/10.1074/jbc.271.25.14981	journal	June 1996
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene Paulusma, C. C.; Bosma, P. J.; Zaman, G. J. R. Science, Vol. 271, Issue 5252 https://doi.org/10.1126/science.271.5252.1126	journal	February 1996
Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Berhane, K.; Widersten, M.; Engstrom, A. Proceedings of the National Academy of Sciences, Vol. 91, Issue 4 https://doi.org/10.1073/pnas.91.4.1480	journal	February 1994
The ABC of channel regulation Higgins, Christopher F. Cell, Vol. 82, Issue 5 https://doi.org/10.1016/0092-8674(95)90465-4	journal	September 1995
Peroxidase-Induced Wilting in Transgenic Tobacco Plants. Lagrimini, L. M.; Bradford, S.; Rothstein, S. The Plant Cell https://doi.org/10.1105/tpc.2.1.7	journal	January 1990
[27] Preparation of high molecular weight RNA Köhrer, Karl; Domdey, Horst Guide to Yeast Genetics and Molecular Biology https://doi.org/10.1016/0076-6879(91)94030-G	book	January 1991
ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione by plasma membrane vesicles from rat liver Kunst, Manuel; Sies, Helmut; Akerboom, Theodorus P. M. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 983, Issue 1 https://doi.org/10.1016/0005-2736(89)90389-1	journal	July 1989
Phytoremediation of contaminated soils Cunningham, Scott D.; Berti, William R.; Huang, Jianwei W. Trends in Biotechnology, Vol. 13, Issue 9 https://doi.org/10.1016/S0167-7799(00)88987-8	journal	September 1995
Cadmium-Sensitive, cad1 Mutants of Arabidopsis thaliana Are Phytochelatin Deficient Howden, R.; Goldsbrough, P. B.; Andersen, C. R. Plant Physiology, Vol. 107, Issue 4 https://doi.org/10.1104/pp.107.4.1059	journal	April 1995
Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles Li, Z. S.; Zhao, Y.; Rea, P. A. Plant Physiology, Vol. 107, Issue 4 https://doi.org/10.1104/pp.107.4.1257	journal	April 1995
Complex formation of zinc and cadmium with glutathione Perrin, D. D.; Watt, Ann E. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 230, Issue 1 https://doi.org/10.1016/0304-4165(71)90057-2	journal	January 1971
A simple method for displaying the hydropathic character of a protein Kyte, Jack; Doolittle, Russell F. Journal of Molecular Biology, Vol. 157, Issue 1, p. 105-132 https://doi.org/10.1016/0022-2836(82)90515-0	journal	May 1982
Glutathione, a first line of defense against cadmium toxicity Singhal, Rakesh K.; Anderson, Mary E.; Meister, Alton The FASEB Journal, Vol. 1, Issue 3 https://doi.org/10.1096/fasebj.1.3.2887478	journal	September 1987
ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates Ishikawa, T. Journal of Biological Chemistry, Vol. 264, Issue 29 https://doi.org/10.1016/S0021-9258(18)71498-1	journal	October 1989
Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. Wemmie, J. A.; Szczypka, M. S.; Thiele, D. J. Journal of Biological Chemistry, Vol. 269, Issue 51 https://doi.org/10.1016/S0021-9258(18)31675-2	journal	December 1994
A guanosine diphosphatase enriched in Golgi vesicles of Saccharomyces cerevisiae. Purification and characterization. Yanagisawa, K.; Resnick, D.; Abeijon, C. Journal of Biological Chemistry, Vol. 265, Issue 31 https://doi.org/10.1016/S0021-9258(17)30665-8	journal	November 1990
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale DeRisi, J. L.; Iyer, Vishwanath R.; Brown, Patrick O. Science, Vol. 278, Issue 5338, p. 680-686 https://doi.org/10.1126/science.278.5338.680	journal	October 1997
The isoflavonoid phytoalexin pathway: From enzymes to genes to transcription factors Dixon, Richard A.; Harrison, Maria J.; Paiva, Nancy L. Physiologia Plantarum, Vol. 93, Issue 2 https://doi.org/10.1034/j.1399-3054.1995.930225.x	journal	February 1995
Tridiphane [2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane] an atrazine synergist: Enzymatic conversion to a potent glutathione S-transferase inhibitor Lamoureux, Gerald L.; Rusness, Donald G. Pesticide Biochemistry and Physiology, Vol. 26, Issue 3 https://doi.org/10.1016/0048-3575(86)90074-X	journal	December 1986
The Transport of Oxidized Glutathione from Human Erythrocytes Srivastava, S. K.; Beutler, E. Journal of Biological Chemistry, Vol. 244, Issue 1 https://doi.org/10.1016/S0021-9258(19)78182-4	journal	January 1969
A gene proposed to encode a transmembrane domain of an ABC transporter is expressed in wheat mitochondria Bonnard, Géraldine; Grienenberger, Jean Michel Molecular and General Genetics MGG, Vol. 246, Issue 1 https://doi.org/10.1007/BF00290137	journal	January 1995
Plant genetic engineering may help with environmental cleanup. Raskin, I. Proceedings of the National Academy of Sciences, Vol. 93, Issue 8 https://doi.org/10.1073/pnas.93.8.3164	journal	April 1996
Basic local alignment search tool Altschul, Stephen F.; Gish, Warren; Miller, Webb Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410 https://doi.org/10.1016/S0022-2836(05)80360-2	journal	October 1990
The Yeast Cadmium Factor Protein (YCF1) Is a Vacuolar Glutathione S-Conjugate Pump Li, Ze-Sheng; Szczypka, Mark; Lu, Yu-Ping Journal of Biological Chemistry, Vol. 271, Issue 11 https://doi.org/10.1074/jbc.271.11.6509	journal	March 1996
GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. Ishikawa, T.; Wright, C. D.; Ishizuka, H. Journal of Biological Chemistry, Vol. 269, Issue 46 https://doi.org/10.1016/S0021-9258(19)62016-8	journal	November 1994
[44] Methods for studying the yeast vacuole Roberts, Christopher J.; Raymond, Christopher K.; Yamashiro, Carl T. Guide to Yeast Genetics and Molecular Biology https://doi.org/10.1016/0076-6879(91)94047-G	book	January 1991
A glutathione S-transferase involved in vacuolar transfer encoded by the maize gene Bronze-2 Marrs, Kathleen A.; Alfenito, Mark R.; Lloyd, Alan M. Nature, Vol. 375, Issue 6530 https://doi.org/10.1038/375397a0	journal	June 1995
Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter Oude Elferink, R. Hepatology, Vol. 17, Issue 3 https://doi.org/10.1016/0270-9139(93)90056-S	journal	March 1993
GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Wu, A. L.; Moye-Rowley, W. S. Molecular and Cellular Biology, Vol. 14, Issue 9 https://doi.org/10.1128/MCB.14.9.5832	journal	September 1994
Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport Hyde, Stephen C.; Emsley, Paul; Hartshorn, Michael J. Nature, Vol. 346, Issue 6282 https://doi.org/10.1038/346362a0	journal	July 1990
How Plants Dispose of Chlorophyll Catabolites Hinder, Brigitte; Schellenberg, Maya; Rodoni, Simona Journal of Biological Chemistry, Vol. 271, Issue 44 https://doi.org/10.1074/jbc.271.44.27233	journal	November 1996
Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae Hirata, Dai; Yano, Kiichiro; Miyakawa, Tokichi Molecular and General Genetics MGG, Vol. 242, Issue 3 https://doi.org/10.1007/BF00280413	journal	February 1994
GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. Jefferson, R. A.; Kavanagh, T. A.; Bevan, M. W. The EMBO Journal, Vol. 6, Issue 13 https://doi.org/10.1002/j.1460-2075.1987.tb02730.x	journal	December 1987
Site-directed Mutagenesis of Vacuolar H+-pyrophosphatase Kim, Eugene J.; Zhen, Rui-Guang; Rea, Philip A. Journal of Biological Chemistry, Vol. 270, Issue 6 https://doi.org/10.1074/jbc.270.6.2630	journal	February 1995
Glutathione S-Transferases: Gene Structure and Regulation of Expression Daniel, Violet Critical Reviews in Biochemistry and Molecular Biology, Vol. 28, Issue 3 https://doi.org/10.3109/10409239309086794	journal	January 1993
The reaction and assay of glutathione with Hg2+ and alkali Kapoor, R.; Doughty, G.; Gorin, G. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 100, Issue 2 https://doi.org/10.1016/0304-4165(65)90006-1	journal	May 1965
Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier Gietz, R. Daniel; Schiestl, Robert H. Yeast, Vol. 7, Issue 3 https://doi.org/10.1002/yea.320070307	journal	April 1991
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Zaman, G. J.; Lankelma, J.; van Tellingen, O. Proceedings of the National Academy of Sciences, Vol. 92, Issue 17 https://doi.org/10.1073/pnas.92.17.7690	journal	August 1995
Induction of Cold Stability of Microtubules in Cultured Tobacco Cells Mizuno, Koichi Plant Physiology, Vol. 100, Issue 2 https://doi.org/10.1104/pp.100.2.740	journal	October 1992
Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene. Friling, R. S.; Bergelson, S.; Daniel, V. Proceedings of the National Academy of Sciences, Vol. 89, Issue 2 https://doi.org/10.1073/pnas.89.2.668	journal	January 1992
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line Cole, S.; Bhardwaj, G.; Gerlach, J. Science, Vol. 258, Issue 5088 https://doi.org/10.1126/science.1360704	journal	December 1992
A simplification of the protein assay method of Lowry et al. which is more generally applicable Peterson, Gary L. Analytical Biochemistry, Vol. 83, Issue 2 https://doi.org/10.1016/0003-2697(77)90043-4	journal	December 1977
ATP-dependent glutathione S-conjugate 'export' pump in the vacuolar membrane of plants Martinoia, Enrico; Grill, Erwin; Tommasini, Roberto Nature, Vol. 364, Issue 6434 https://doi.org/10.1038/364247a0	journal	July 1993
Quantitative assessment of worldwide contamination of air, water and soils by trace metals Nriagu, Jerome O.; Pacyna, Jozef M. Nature, Vol. 333, Issue 6169 https://doi.org/10.1038/333134a0	journal	May 1988
Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. Shrieve, D. C.; Bump, E. A.; Rice, G. C. Journal of Biological Chemistry, Vol. 263, Issue 28 https://doi.org/10.1016/S0021-9258(18)68191-8	journal	October 1988
Some Metal Complexes of Sulfur-containing Amino Acids ^1,2 Li, Norman C.; Manning, Richard A. Journal of the American Chemical Society, Vol. 77, Issue 20 https://doi.org/10.1021/ja01625a006	journal	October 1955
The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression Ishikawa, Toshihisa; Li, Ze-Sheng; Lu, Yu-Ping Bioscience Reports, Vol. 17, Issue 2 https://doi.org/10.1023/A:1027385513483	journal	April 1997
α-d-mannosidase of Saccharomyces cerevisiae Characterization and modulation of activity Opheim, Dennis J. Biochimica et Biophysica Acta (BBA) - Enzymology, Vol. 524, Issue 1 https://doi.org/10.1016/0005-2744(78)90110-9	journal	May 1978
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. Walker, J. E.; Saraste, M.; Runswick, M. J. The EMBO Journal, Vol. 1, Issue 8 https://doi.org/10.1002/j.1460-2075.1982.tb01276.x	journal	August 1982
Breathing easier with DFMA Parker, Miles World Class Design to Manufacture, Vol. 2, Issue 6 https://doi.org/10.1108/09642369310104255	journal	December 1995
Phosphatidylcholine translocase: A physiological role for the mdr2 gene Ruetz, S. Cell, Vol. 77, Issue 7 https://doi.org/10.1016/0092-8674(94)90446-4	journal	July 1994

Similar Records

Methods for transforming and expression screening of filamentous fungal cells with a DNA library

Patent · Tue Jun 02 00:00:00 EDT 2015 · OSTI ID:873465

Teter, Sarah; Lamsa, Michael; Cherry, Joel; +1 more

Nucleic acids encoding antifungal polypeptides and uses thereof

Patent · Tue Nov 02 00:00:00 EDT 2010 · OSTI ID:873465

Altier, Daniel J; Ellanskaya, I A; Gilliam, Jacob T; +6 more

Antifungal polypeptides

Patent · Tue Apr 12 00:00:00 EDT 2011 · OSTI ID:873465

Altier, Daniel J; Dahlbacka, Glen; Elleskaya, Irina; +9 more

Related Subjects

glutathione-s-conjugate
transport
plants
isolated
dna
encoding
plant
gs-x
pump
polypeptide
preparation
included
nucleic
acid
antisense
orientation
portion
cells
vectors
transgenic
methods
addition
relates
promoter
sequences
plant gs-x
isolated dna
nucleic acid
transgenic plants
dna encoding
promoter sequence
gs-x pump
pump polypeptide
transgenic plant
isolated preparation
/800/435/999/

Title: Glutathione-S-conjugate transport in plants

Citation Formats

References (72)

Similar Records

Related Subjects