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Title: Inhibitors of glycogen synthase 3 kinase

Abstract

Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

Inventors:
 [1];  [2];  [3];  [4]
  1. Oakland, CA
  2. Palo Alto, CA
  3. Berkeley, CA
  4. Victoria, AU
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
873412
Patent Number(s):
US 6153618
Assignee:
Chiron Corporation (Emeryville, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
inhibitors; glycogen; synthase; kinase; compounds; formula; str1; alkyl; cycloalkyl; aryl; aralkyl; heteroaryl; heteroaralkyl; substituted; 0-3; substituents; selected; halo; hydroxy; alkoxy; amino; alkyl-amino; nitro; acyl; alkoxy-acyl; amnino-acyl; pharmaceutically; acceptable; salts; esters; effective; gsk3; substituents selected; pharmaceutically acceptable; acceptable salt; /514/999/

Citation Formats

Schultz, Peter, Ring, David B, Harrison, Stephen D, and Bray, Andrew M. Inhibitors of glycogen synthase 3 kinase. United States: N. p., 2000. Web.
Schultz, Peter, Ring, David B, Harrison, Stephen D, & Bray, Andrew M. Inhibitors of glycogen synthase 3 kinase. United States.
Schultz, Peter, Ring, David B, Harrison, Stephen D, and Bray, Andrew M. Sat . "Inhibitors of glycogen synthase 3 kinase". United States. https://www.osti.gov/servlets/purl/873412.
@article{osti_873412,
title = {Inhibitors of glycogen synthase 3 kinase},
author = {Schultz, Peter and Ring, David B and Harrison, Stephen D and Bray, Andrew M},
abstractNote = {Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.},
doi = {},
url = {https://www.osti.gov/biblio/873412}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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