Kit for providing a technetium medical radioimaging agent

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873391

Wildung, Raymond E ^[1]; Garland, Thomas R ^[2]; Li, Shu-Mei W ^[1]

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1. Richland, WA
2. Greybull, WY

The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.

• Research Organization: Battelle Memorial Institute, Columbus, OH (United States)
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Richland, WA)
• Patent Number(s): US 6150155
• OSTI ID: 873391
• Country of Publication: United States
• Language: English

Related Subjects

kit
providing
technetium
medical
radioimaging
agent
directed
microbial
reduction
compound
form
compounds
value
imaging
combined
mixture
non-growing
cells
contain
technetium-reducing
enzyme
stabilizing
electron
donor
saline
solution
anaerobic
conditions
substantially
free
inorganic
reducing
products
resulting
product
tc
oxidation
partially
controlled
discovered
microorganisms
shewanella
alga
strain
bry
putrifacians
cn-32
systems
mono
nuclear
polynuclear
reduced
species
depending
saline solution
resulting product
substantially free
reducing agent
anaerobic conditions
electron donor
stabilizing agent
microbial reduction
medical imaging
imaging agent
technetium compound
microbial cell
aerobic conditions
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