Miniature reaction chamber and devices incorporating same

Mathies, Richard A; Woolley, Adam T

Title: Miniature reaction chamber and devices incorporating same

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873308

Mathies, Richard A ^[1]; Woolley, Adam T ^[2]

Moraga, CA
Albany, CA

The present invention generally relates to miniaturized devices for carrying out and controlling chemical reactions and analyses. In particular, the present invention provides devices which have miniature temperature controlled reaction chambers for carrying out a variety of synthetic and diagnostic applications, such as PCR amplification, nucleic acid hybridization, chemical labeling, nucleic acid fragmentation and the like.

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Research Organization:: Univ. of California (United States)

DOE Contract Number:: FG03-91ER61125

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 6132580

Application Number:: 08/535875

OSTI ID:: 873308

Country of Publication:: United States

Language:: English

References (14)

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High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device Effenhauser, Carlo S.; Paulus, Aran.; Manz, Andreas. Analytical Chemistry, Vol. 66, Issue 18 https://doi.org/10.1021/ac00090a024	journal	September 1994
Planar chips technology for miniaturization and integration of separation techniques into monitoring systems Manz, Andreas; Harrison, D. Jed; Verpoorte, Elisabeth M. J. Journal of Chromatography A, Vol. 593, Issue 1-2 https://doi.org/10.1016/0021-9673(92)80293-4	journal	February 1992
Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips. Woolley, A. T.; Mathies, R. A. Proceedings of the National Academy of Sciences, Vol. 91, Issue 24 https://doi.org/10.1073/pnas.91.24.11348	journal	November 1994
DNA Helicases Kuhn, B.; Abdel-Monem, M.; Hoffmann-Berling, H. Cold Spring Harbor Symposia on Quantitative Biology, Vol. 43, Issue 0 https://doi.org/10.1101/SQB.1979.043.01.011	journal	January 1979
Light-directed, spatially addressable parallel chemical synthesis Fodor, S.; Read, J.; Pirrung, M. Science, Vol. 251, Issue 4995 https://doi.org/10.1126/science.1990438	journal	February 1991
Gene Readers Stix, Gary Scientific American, Vol. 270, Issue 1 https://doi.org/10.1038/scientificamerican0194-149	journal	January 1994
Liquid transport in micron and submicron channels Pfahler, J.; Harley, J.; Bau, H. Sensors and Actuators A: Physical, Vol. 22, Issue 1-3 https://doi.org/10.1016/0924-4247(89)80008-1	journal	June 1990
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 7 https://doi.org/10.1021/ac00079a028	journal	April 1994
High-Speed Separations on a Microchip Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 7 https://doi.org/10.1021/ac00079a029	journal	April 1994
DNA fingerprinting by sampled sequencing. Brenner, S.; Livak, K. J. Proceedings of the National Academy of Sciences, Vol. 86, Issue 22 https://doi.org/10.1073/pnas.86.22.8902	journal	November 1989
Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections Fan, Zhonghui H.; Harrison, D. Jed. Analytical Chemistry, Vol. 66, Issue 1 https://doi.org/10.1021/ac00073a029	journal	January 1994
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip Harrison, D. J.; Fluri, K.; Seiler, K. Science, Vol. 261, Issue 5123 https://doi.org/10.1126/science.261.5123.895	journal	August 1993
Homologous Pairing and Strand Exchange in Genetic Recombination Radding, C. M. Annual Review of Genetics, Vol. 16, Issue 1 https://doi.org/10.1146/annurev.ge.16.120182.002201	journal	December 1982

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pcr
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acid hybridization
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nucleic acid
chemical reaction
chemical reactions
devices incorporating
diagnostic applications
acid fragment
controlled reaction
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Title: Miniature reaction chamber and devices incorporating same

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References (14)

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