Device to improve detection in electro-chromatography

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873013

Garguilo, Michael G ^[1]; Paul, Phillip H ^[1]; Rakestraw, David J ^[2]

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1. Livermore, CA
2. Fremont, CA

Apparatus and method for improving the resolution of non-pressure driven capillary chromatographic systems, and particularly for capillary electrochromatography (CEC) systems. By reducing the cross-sectional area of a packed capillary column by means of a second open capillary contiguous with the outlet end of a packed capillary column, where the packed capillary column has a cross sectional area of between about 2 and 5 times that of the open capillary column, the phenomenon of band broadening in the transition region between the open capillary and the packed capillary column, where the individual components of the mixture are analyzed, can be eliminated, thereby providing for a significant improvement in resolution and more accurate detection and analysis.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• DOE Contract Number: AC04-94AL85000
• Assignee: Sandia Corporation (Livermore, CA)
• Patent Number(s): US 6068767
• OSTI ID: 873013
• Country of Publication: United States
• Language: English

Related Subjects

device
improve
detection
electro-chromatography
apparatus
method
improving
resolution
non-pressure
driven
capillary
chromatographic
systems
particularly
electrochromatography
cec
reducing
cross-sectional
packed
column
means
contiguous
outlet
sectional
times
phenomenon
band
broadening
transition
region
individual
components
mixture
analyzed
eliminated
providing
significant
improvement
accurate
analysis
capillary column
transition region
accurate detection
significant improvement
individual components
individual component
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