Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873009

Mobley, David Paul ^[1]; Shank, Gary Keith ^[2]

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1. Schenectady, NY
2. Rocky Hill, CT

This invention provides a low-cost method of producing .alpha.,.omega.-alkanedicarboxylic acids. Particular bioconversion conditions result in highly efficient conversion of fatty acid, fatty acid ester, or alkane substrates to diacids. Candida tropicalis AR40 or similar yeast strains are grown in a medium containing a carbon source and a nitrogen source at a temperature of 31.degree. C. to 38.degree. C., while additional carbon source is continuously added, until maximum cell growth is attained. Within 0-3 hours of this point, substrate is added to the culture to initiate conversion. An .alpha.,.omega.-alkanedicarboxylic acid made according to this method is also provided.

• Research Organization: GE CORPORATE R & D
• DOE Contract Number: FC36-95GO10099
• Assignee: General Electric Company (Schenectady, NY)
• Patent Number(s): US 6066480
• OSTI ID: 873009
• Country of Publication: United States
• Language: English

Related Subjects

method
specific
bioproductivity
alpha
omega
-alkanedicarboxylic
acids
provides
low-cost
producing
particular
bioconversion
conditions
result
highly
efficient
conversion
fatty
acid
ester
alkane
substrates
diacids
candida
tropicalis
ar40
similar
yeast
strains
grown
medium
containing
carbon
source
nitrogen
temperature
31
degree
38
additional
continuously
added
maximum
cell
growth
attained
0-3
hours
substrate
culture
initiate
according
provided
acid ester
cell growth
highly efficient
carbon source
fatty acid
carboxylic acids
carboxylic acid
medium containing
nitrogen source
efficient conversion
dicarboxylic acid
-alkanedicarboxylic acid
-alkanedicarboxylic acids
dicarboxylic acids
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