skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same

Patent ·
OSTI ID:872966
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Columbia, MO
+ Show Author Affiliations

A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.

Research Organization:
Univ. of Missouri, Columbia, MO (United States)
DOE Contract Number:
FG02-89ER60875
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Number(s):
US 6054115
OSTI ID:
872966
Country of Publication:
United States
Language:
English

References (36)

Syntheses and Structural Characterizations of Six-Coordinate Oxo-M(V) Complexes (M = Tc, Re) Containing a Tetradentate P2N2-Phosphino-Amido Ligand journal March 1995
Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 journal July 1990
Stereochemical Control of Transition Metal Complexes by Polyphosphine Ligands journal July 1994
Coordination chemistry of phosphorus(III) and phosphorus(V) hydrazides journal January 1995
In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP) journal July 1996
Synthesis, characterization, and electrochemical properties of tertiary diphosphine complexes of technetium: single-crystal structure of the prototype complex trans-[Tc(DPPE)2Br2]BF4 journal June 1983
An isothiocyanato complex of technetium(II). Spectroelectrochemical and single-crystal x-ray structural studies on trans-[Tc(DPPE)2(NCS)2]0, where DPPE = 1,2-bis(diphenylphosphino)ethane journal August 1984
Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling journal November 1992
Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
  • Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8 https://doi.org/10.1016/0883-2897(92)90175-X
journal November 1992
An empirical correction for absorption anisotropy journal January 1995
Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis journal October 1999
Chemical and physical properties of radionuclides journal January 1987
Water soluble, zero-valent, platinum–, palladium–, and nickel–P(CH 2 OH) 3 complexes:catalysts for the addition of PH 3 to CH 2 O journal January 1989
Phase annealing in SHELX-90: direct methods for larger structures journal June 1990
Medical Diagnostic Imaging with Complexes of 99mTc journal May 1987
Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3 journal July 1992
Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2 journal January 1996
Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery. journal April 1993
The Preparation and Properties of [Re(amine) 4 O 2 ] + Type Ions journal June 1965
New advances in the synthesis of a water-soluble triphosphine and the development of tripodally coordinated rhodium(I) and platinum(II) complexes journal January 1996
Co-ordination of (o-aminophenyl)diphenylphosphine in complexes containing the [Mv= O]3+(M = Tc or Re) core journal January 1993
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal June 1988
Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR n Q 3–n (n= 0,1, or 2; R = Me, Et, Bu t , or Ph; Q = CH 2 OCOMe or CH 2 OH) journal January 1973
Chemistry in environmentally benign media Part 1. Synthesis and characterization of 1,2-bis[bis(hydroxymethyl)phosphino]ethane (‘HMPE’). X-ray structure of [Pt{(HOH2C)2PCH2CH2P(CH2OH)2}2](Cl)2 journal December 1995
Technetium electrochemistry. 2. Electrochemical and spectroelectrochemical studies of the bis(tertiary phosphine) (D) complexes trans-[TcIIID2X2]+ (X =chlorine or bromine) journal April 1984
Synthesis and characterization of cationic technetium complexes of 1,2-bis(dimethylphosphino)ethane (DMPE). Structure determinations of trans-[TcV(DMPE)2(OH)(O)](F3CSO3)2, trans-[TcIII(DMPE)2Cl2]F3CSO3, and [TcI(DMPE)3]+ using x-ray diffraction, EXAFS, and technetium-99 NMR journal September 1984
Antibody radiolabeling, problems and promises journal January 1990
Comparison of the chemical and biological properties of trans-[Tc(DMPE)2Cl2]+ and trans-[Re(DMPE)2Cl2]+, where DMPE = 1,2-bis(dimethylphosphino)ethane. Single-crystal structural analysis of trans-[Re(DMPE)2Cl2]PF6 journal May 1985
Aspects of the Chemistry of Technetium Phosphine Complexes journal January 1993
Coordination compounds in nuclear medicine journal May 1993
Synthesis and characterization of dioxorhenium complexes derived from water-soluble diphosphine tetraphosphonates journal January 1996
Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands journal September 1991
Recent Developments in Peptide Drug Delivery to the Brain journal July 1992
Chemistry in Environmentally Benign Media. 3. 1 Synthesis and Characterization of Rhenium(V) Complexes Derived from Novel Water-Soluble (Hydroxymethyl)phosphines. Crystal Structures of [Re(O) 2 {(HOH 2 C) 2 PC 6 H 4 P(CH 2 OH) 2 } 2 ]I and [Re(O) 2 {(HOH 2 C) 2 PCH 2 CH 2 P(CH 2 OH) 2 } 2 ]Cl journal January 1996
Tumour targeting with radiolabelled macrocycle–antibody conjugates journal January 1990
Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver journal January 1988

Similar Records

Related Subjects

hydroxymethyl
phosphine
compounds
diagnostic
therapeutic
pharmaceuticals
method
compound
pharmaceutical
comprises
functionalized
hydroxyalkyl
donor
sulfur
nitrogen
metal
combined
ligand
therapeutic pharmaceutical
hydroxyalkyl phosphine
metal combined
phosphine donor
phosphine compounds
pharmaceutical comprises
therapeutic pharmaceuticals
functionalized hydroxyalkyl
hydroxymethyl phosphine
/424/999/