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Title: Boron-containing amino carboxylic acid compounds and uses thereof

Abstract

Novel compounds which are useful for boron neutron capture therapy (BNCT) are disclosed. The compounds comprise a stable boron-containing group and an aminocycloalkane carboxylic acid group or a boronated acyclic hydrocarbon-linked amino carboxylic acid. Methods for synthesis of the compounds and for use of the compounds in BNCT are disclosed.

Inventors:
 [1];  [1]
  1. Knoxville, TN
Publication Date:
Research Org.:
Univ. of Tennessee, Knoxville, TN (United States)
OSTI Identifier:
872909
Patent Number(s):
US 6037490
Application Number:
08/923,054
Assignee:
University of Tennessee Research Corporation (Knoxville, TN)
DOE Contract Number:  
FG05-93ER61610
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
boron-containing; amino; carboxylic; acid; compounds; novel; useful; boron; neutron; capture; therapy; bnct; disclosed; comprise; stable; aminocycloalkane; boronated; acyclic; hydrocarbon-linked; methods; synthesis; neutron capture; boron neutron; carboxylic acid; capture therapy; novel compounds; acid compounds; acid compound; containing amino; compounds comprise; novel compound; /999/

Citation Formats

Kabalka, George W, and Srivastava, Rajiv R. Boron-containing amino carboxylic acid compounds and uses thereof. United States: N. p., 2000. Web.
Kabalka, George W, & Srivastava, Rajiv R. Boron-containing amino carboxylic acid compounds and uses thereof. United States.
Kabalka, George W, and Srivastava, Rajiv R. 2000. "Boron-containing amino carboxylic acid compounds and uses thereof". United States. https://www.osti.gov/servlets/purl/872909.
@article{osti_872909,
title = {Boron-containing amino carboxylic acid compounds and uses thereof},
author = {Kabalka, George W and Srivastava, Rajiv R},
abstractNote = {Novel compounds which are useful for boron neutron capture therapy (BNCT) are disclosed. The compounds comprise a stable boron-containing group and an aminocycloalkane carboxylic acid group or a boronated acyclic hydrocarbon-linked amino carboxylic acid. Methods for synthesis of the compounds and for use of the compounds in BNCT are disclosed.},
doi = {},
url = {https://www.osti.gov/biblio/872909}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 14 00:00:00 EST 2000},
month = {Tue Mar 14 00:00:00 EST 2000}
}

Works referenced in this record:

Hydroboration of vinylglycine and allylglycine as a route to boron-derivatives of α-amino acids
journal, July 1996


Novel polypyrazolylborate ligands: coordination control through 3-substituents of the pyrazole ring
journal, May 1987


Inhibition of Mn 2+ 2 -Arginase by Borate Leads to the Design of a Transition State Analogue Inhibitor, 2( S )-Amino-6-boronohexanoic Acid
journal, August 1997