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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Patent ·
OSTI ID:872888
 [1]
  1. Knoxville, TN
+ Show Author Affiliations

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
DOE Contract Number:
AC05-84OR21400
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
Patent Number(s):
US 6033546
OSTI ID:
872888
Country of Publication:
United States
Language:
English

References (10)

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis journal June 1994
Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights journal October 1993
Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency journal May 1993
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal April 1994
Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze? journal May 1991
High-Speed Separations on a Microchip journal April 1994
Electric sample splitter for capillary zone electrophoresis journal February 1985
Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections journal January 1994
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip journal August 1993
Capillary electrophoresis and sample injection systems integrated on a planar glass chip journal September 1992

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apparatus
method
performing
microfluidic
manipulations
chemical
analysis
synthesis
microchip
laboratory
provide
fluid
variety
applications
including
sample
injection
separations
fabricated
standard
photolithographic
procedures
wet
etching
substrate
cover
plate
joined
direct
bonding
capillary
electrophoresis
electrochromatography
performed
channels
formed
analytes
loaded
four-way
intersection
electrokinetically
pumping
analyte
followed
switching
potentials
force
plug
separation
channel
chemical separations
separation channel
chemical wet
performing microfluidic
microfluidic manipulations
photolithographic procedures
plate joined
standard photolithographic
channels formed
chemical analysis
capillary electrophoresis
cover plate
sample injection
method provide
wet etching
provide fluid
microchip chemical
microchip laboratory
direct bonding
including sample
electrokinetically pumping
fluid manipulations
four-way intersection
analyte plug
chemical separation
fluidic manipulations
lithographic procedures
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