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Title: Boron containing amino acid compounds and methods for their use

Patent ·
OSTI ID:872828
 [1];  [2]
  1. Shoreham, NY
  2. Wading River, NY
+ Show Author Affiliations

The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
DOE Contract Number:
AC02-98CH10886
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Number(s):
US 6017902
OSTI ID:
872828
Country of Publication:
United States
Language:
English

References (5)

Accumulation of Boron in Malignant and Normal Cells Incubated In Vitro with Boronophenylalanine, Mercaptoborane or Boric Acid journal November 1996
Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results journal May 1997
Neutron capture therapy of the 9l rat gliosarcoma using the P-boronophenylalanine-fructose complex journal October 1994
Microanalytical techniques for boron analysis using the 1 0 B( n ,α) 7 Li reaction: Microanalysis for boron by the 1 0 B( n ,α) 7 Li reaction journal January 1986
Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice journal February 1992

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boron
containing
amino
acid
compounds
methods
provides
contacting
melphalan
nitrogen
mustard
derivative
sodium
borocaptate
method
treating
mammal
tumor
administering
therapeutically
effective
amount
boron containing
effective amount
amino acid
acid compounds
acid compound
containing amino
therapeutically effective
/514/999/