Inhibition of selectin binding

Nagy, Jon O; Spevak, Wayne R; Dasgupta, Falguni; Bertozzi, Caroline

Title: Inhibition of selectin binding

Patent · Fri Jan 01 00:00:00 EST 1999

OSTI ID:872672

Nagy, Jon O ^[1]; Spevak, Wayne R ^[2]; Dasgupta, Falguni ^[3]; Bertozzi, Caroline ^[2]

Rodeo, CA
Albany, CA
New Delhi, IN

This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California ()

Patent Number(s):: US 5985852

OSTI ID:: 872672

Country of Publication:: United States

Language:: English

References (61)

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Related Subjects

inhibition
selectin
binding
provides
compositions
inhibiting
cells
expressing
p-
l-selectin
surface
corresponding
ligand
covalently
crosslinked
lipid
composition
prepared
saccharides
acidic
separate
lipids
interposed
inhibit
achieved
effective
oligosaccharide
concentration
10
fold
below
free
saccharide
selectins
involved
recruiting
sites
injury
scan
palliate
inflammatory
immunological
conditions
recruiting cells
provides compositions
selectin binding
separate lipids
oligosaccharide concentration
expressing p-
fold below
free saccharide
lipid composition
effective oligosaccharide
covalently crosslinked
crosslinked lipid
corresponding ligand
immunological conditions
inhibit binding
/514/424/999/

Title: Inhibition of selectin binding

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References (61)

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