Micro injector sample delivery system for charged molecules

Patent · 09 November 1999

OSTI ID:872645

Davidson, James C ^[1]; Balch, Joseph W ^[1]

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1. Livermore, CA

A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5980713
• Application Number: 08/705447
• OSTI ID: 872645
• Country of Publication: United States
• Language: English

Related Subjects

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96
acids
amounts
analysis
analytical
application
applying
appropriate
automated
bias
bias potential
biological
biological molecules
charged
charged biological
charged molecule
charged molecules
collecting
controllable
controlled
controlled amount
controlled amounts
delivering
delivery
delivery systems
ejected
electric
electric field
essence
etc
field
field control
forced
including
injector
injector sample
loading
massively
massively parallel
material
micro
micro injector
migrate
molecule
molecules
nucleic
nucleic acid
nucleic acids
parallel
polarity
polymers
porous
porous material
potential
proteins
reversing
sample
sample delivery
samples
scaled
section
subsequent
subsequent analysis
systems
throughput
tip
uptake