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Neutron capture therapies

Patent ·
OSTI ID:872624
 [1];  [2];  [3]
  1. Cambridge, MA
  2. Newton, MA
  3. Winchester, MA
+ Show Author Affiliations

In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.

Research Organization:
Massachusetts Institute of Technology (Cambridge, MA); Newton Scientific, Inc. (Cambridge, MA)
DOE Contract Number:
FG02-89ER60874
Assignee:
Massachusetts Institute of Technology (Cambridge, MA); Newton Scientific, Inc. (Cambridge, MA)
Patent Number(s):
US 5976066
OSTI ID:
872624
Country of Publication:
United States
Language:
English

References (2)

Accelerator-based Epithermal Neutron Sources for Boron Neutron Capture Therapy of Brain Tumors journal March 2003
Accelerator-based epithermal neutron beam design for neutron capture therapy journal May 1992

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Related Subjects

/600/
10
accelerator-based
addition
alpha
altered
application
arthritic
arthritis
assemblies
based
beam
beams
beryllium
bncs
bnct
boron
boron neutron
called
capture
capture reactions
capture therapy
charged
charged particle
comparisons
considerations
deep
demands
design
deuterium
deuteron
deuteron-based
embodiment
energies
epithermal
exemplary
high-quality
instance
intense
joints
moderator
neutron
neutron beam
neutron beams
neutron capture
nuclear
nuclear reaction
particle
produce
prolific
provided
reaction
reactions
reflector
relatively
requirements
requires
rheumatoid
rheumatoid arthritis
seated
sources
substantially
synovectomy
targets
therapies
therapy
thermal
thermal neutron
treatment
tritium
tumors
via