Thin film composition with biological substance and method of making

Patent · Fri Jan 01 00:00:00 EST 1999

OSTI ID:872539

Campbell, Allison A ^[1]; Song, Lin ^[2]

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1. Kennewick, WA
2. Richland, WA

The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and organic amorphus structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobal, radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflamatory, steriod, nonsteriod anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor the compositions listed above.

• Research Organization: Battelle Memorial Institute, Columbus, OH (United States)
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Richland, WA)
• Patent Number(s): US 5958430
• OSTI ID: 872539
• Country of Publication: United States
• Language: English

Related Subjects

film
composition
biological
substance
method
provides
thin-film
comprising
underlying
substrate
material
including
plurality
attachment
sites
functional
chemically
attached
deposited
biologically
active
preferably
assembling
monolayer
preferred
chosen
consisting
carboxylates
sulfonates
phosphates
optionally
substituted
linear
cyclo
alkyl
alkene
alkyne
aryl
alkylaryl
amine
hydroxyl
thiol
silyl
phosphoryl
cyano
metallocenyl
carbonyl
polyphosphate
materials
selected
metal
alloy
plastic
polymer
proteic
membrane
glass
ceramic
inorganic
crystalline
structures
amorphus
organic
especially
calcium
particularly
apatite
molecule
protein
peptide
dna
segment
rna
nucleotide
polynucleotide
nucleoside
antibiotic
antimicrobal
radioisotope
chelated
salt
anti-inflamatory
steriod
nonsteriod
anti-inflammatory
analgesic
antihistamine
receptor
binding
agent
chemotherapeutic
osteogenic
factor
compositions
listed
biologically active
biological substance
material deposited
binding agent
crystalline structures
underlying substrate
composition comprising
active material
metal alloy
metal salt
dna segment
material including
crystalline structure
therapeutic agent
calcium phosphate
preferred materials
optionally substituted
particularly calcium
layer attached
active substance
line structure
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