Method for preparing radionuclide-labeled chelating agent-ligand complexes

Meares, Claude F; Li, Min; DeNardo, Sally J

Method for preparing radionuclide-labeled chelating agent-ligand complexes

Patent · 31 December 1998

OSTI ID:872538

Meares, Claude F ^[1]; Li, Min ^[1]; DeNardo, Sally J ^[2]

Davis, CA
El Macero, CA

Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.

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Research Organization:: University of California

DOE Contract Number:: FG03-84ER60233

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5958374

OSTI ID:: 872538

Country of Publication:: United States

Language:: English

References (17)

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Method for preparing radionuclide-labeled chelating agent-ligand complexes

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References (17)

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