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Title: Method for preparing radionuclide-labeled chelating agent-ligand complexes

Patent ·
OSTI ID:872538
 [1];  [1];  [2]
  1. Davis, CA
  2. El Macero, CA
+ Show Author Affiliations

Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.

Research Organization:
Univ. of California (United States)
DOE Contract Number:
FG03-84ER60233
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5958374
OSTI ID:
872538
Country of Publication:
United States
Language:
English

References (17)

Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates journal July 1993
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal June 1988
Immunochemical aspects of monoclonal antibodies important for radiopharmaceutical development
  • DeNardo, Sally J.; Peng, Jo-Sen B.; DeNardo, Gerald L.
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 13, Issue 4 https://doi.org/10.1016/0883-2897(86)90002-4
journal January 1986
A kinetic investigation of the lanthanide DOTA chelates. Stability and rates of formation and of dissociation of a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agent journal March 1992
Newer approaches to the radiolabeling of monoclonal antibodies by use of metal chelates journal January 1991
The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent journal January 1987
Synthesis of C- and N-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-triyltriacetic acid (NOTA), 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrayltetra-acetic acid (DOTA), and diethylenenetriaminepenta-acetic acid (DTPA): bifunctional complexing agents for the derivatisation of antibodies journal January 1990
Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions journal October 1984
Thermodynamic and kinetic studies of lanthanide complexes of 1,4,7,10,13-pentaazacyclopentadecane-N,N',N'',N''',N''''-pentaacetic acid and 1,4,7,10,13,16-hexaazacyclooctadecane-N,N',N'',N''',N'''',N'''''-hexaacetic acid journal March 1991
Kinetics of interaction of metal ions with two tetraazatetraacetate macrocycles journal September 1982
Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC [phenyl isothiocyanate]. journal May 1991
The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex journal August 1988
Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent journal July 1985
[47] A centrifuged-column procedure for the measurement of ligand binding by beef heart F1 book January 1979
Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies: Radionuclide selection and dose calculations for labeled antibodies journal September 1984
Chimeric L6 anti-tumor antibody. Genomic construction, expression, and characterization of the antigen binding site. journal August 1992
Tumour targeting with radiolabelled macrocycle–antibody conjugates journal January 1990

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Related Subjects

method
preparing
radionuclide-labeled
chelating
agent-ligand
complexes
useful
medical
diagnosis
therapy
prepared
reacting
radionuclide
90
111
polyfunctional
agent
form
chelate
electrically
neutral
purifying
anion
exchange
chromatography
purified
targeting
molecule
monoclonal
antibody
complex
monoclonal antibody
anion exchange
chelating agent
radionuclide-labeled chelating
chelating agent-ligand
medical diagnosis
exchange chromatography
agent-ligand complexes
ligand complex
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