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Title: Method for preparing radionuclide-labeled chelating agent-ligand complexes

Abstract

Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.

Inventors:
 [1];  [1];  [2]
  1. (Davis, CA)
  2. (El Macero, CA)
Publication Date:
Research Org.:
University of California
OSTI Identifier:
872538
Patent Number(s):
US 5958374
Assignee:
Regents of University of California (Oakland, CA) OAK
DOE Contract Number:  
FG03-84ER60233
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; preparing; radionuclide-labeled; chelating; agent-ligand; complexes; useful; medical; diagnosis; therapy; prepared; reacting; radionuclide; 90; 111; polyfunctional; agent; form; chelate; electrically; neutral; purifying; anion; exchange; chromatography; purified; targeting; molecule; monoclonal; antibody; complex; monoclonal antibody; anion exchange; chelating agent; radionuclide-labeled chelating; chelating agent-ligand; medical diagnosis; exchange chromatography; agent-ligand complexes; ligand complex; /424/999/

Citation Formats

Meares, Claude F., Li, Min, and DeNardo, Sally J. Method for preparing radionuclide-labeled chelating agent-ligand complexes. United States: N. p., 1999. Web.
Meares, Claude F., Li, Min, & DeNardo, Sally J. Method for preparing radionuclide-labeled chelating agent-ligand complexes. United States.
Meares, Claude F., Li, Min, and DeNardo, Sally J. Fri . "Method for preparing radionuclide-labeled chelating agent-ligand complexes". United States. https://www.osti.gov/servlets/purl/872538.
@article{osti_872538,
title = {Method for preparing radionuclide-labeled chelating agent-ligand complexes},
author = {Meares, Claude F. and Li, Min and DeNardo, Sally J.},
abstractNote = {Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Patent:

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