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Title: Activated recombinant adenovirus proteinases

Patent ·
OSTI ID:872441
 [1];  [2]
  1. Stony Brook, NY
  2. Shoreham, NY
+ Show Author Affiliations

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5935840
Application Number:
08/435,998
OSTI ID:
872441
Country of Publication:
United States
Language:
English

References (17)

Sequence of the human adenovirus type 3 protease journal January 1988
Characterization of the adenovirus 2 virion protein, Mu journal October 1989
Nucleotide and deduced amino acid sequence of the bovine adenovirus type 7 proteinase journal January 1990
Expression and Purification of the Adenovirus Proteinase Polypeptide and of a Synthetic Proteinase Substrate journal February 1993
The primary structure of human adenovirus type 12 protease journal January 1988
Adenovirus proteinases: comparison of amino acid sequences and expression of the cloned cDNA in Escherichia coli journal April 1990
Human Adenovirus Serotype 12 Virion Precursors pMu and pVI Are Cleaved at Amino-Terminal and Carboxy-Terminal Sites That Conform to the Adenovirus 2 Endoproteinase Cleavage Consensus Sequence journal March 1993
Adenovirus type 2 endopeptidase: an unusual phosphoprotein enzyme matured by autocatalysis. journal February 1987
In vitro cleavage specificity of the adenovirus type 2 proteinase journal March 1983
Gly-Gly-X, a Novel Consensus Sequence for the Proteolytic Processing of Viral and Cellular Proteins journal June 1989
Nucleotide and deduced amino acid sequence of the bovine adenovirus type 3 proteinase journal January 1990
Adenovirus type 2 precursor proteins are cleaved by proteinases of other adenoviruses journal November 1990
The adenovirus protease is activated by a virus-coded disulphide-linked peptide journal January 1993
Sequence of the protease of human subgroup E adenovirus type 4 journal January 1987
The active adenovirus protease is the intact L3 23K protein journal July 1993
Characterization of the Adenovirus Proteinase: Substrate Specificity journal December 1989
Genetic identification of a endoproteinase endoded by the adenovirus genome journal June 1983

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Related Subjects

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recombinant
adenovirus
proteinases
application
describes
methods
expression
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activatable
purified
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peptide
cofactors
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activity
purifying
identifying
antibodies
immunoreactive
immunospecific
preparing
related
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application describes
adenovirus proteinases
related methods
antibodies immunoreactive
isolated peptide
expression constructs
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purified activatable
describes methods
producing activatable
activated recombinant
adenovirus proteinase
/435/999/